| خلاصه مقاله | Background: Non-alcoholic fatty liver disease (NAFLD) is a liver condition that is increasing globally. Lifestyle interventions play a crucial role in managing NAFLD, but the specific effects of this intervention remain to be fully elucidated. Hence, this study aimed to investigate the effect of therapeutic lifestyle changes (TLCs) on patients with overweight/obesity and non-alcoholic fatty liver disease.
Methods: A prospective, parallel-group, randomized controlled trial was conducted. The patients were randomized into observation and experimental groups using tables with random numbers. In the observation group, routine health guidance was provided for 3 months, while in the experimental group, diversified lifestyle intervention was provided. The body composition, visceral fat area, abdominal circumference, and body mass index of the observation and experimental groups were compared before and after the intervention. Descriptive statistics, paired t-tests, and linear regression models were used for data analysis.
Results: A total of 120 participants (75 in each group) completed the study. The experimental groups had significantly greater high-density lipoprotein cholesterol levels, basal metabolic rate, muscle mass, and questionnaire scores than the observation groups (P < 0.05). Furthermore, the experimental participants had lower body mass index, abdominal circumference, triglyceride levels, low-density lipoprotein cholesterol levels, and fatty liver index (P < 0.05).
Conclusions: TLCs therapy for NAFLD patients with overweight/obesity can significantly control body mass index, improve blood lipid levels, reduce fatty liver and body fat rates, improve basic metabolism, alleviate disease, and improve quality of life. More research is needed to determine the long-term impact TLCs in high-risk groups. |