چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| ثمینا سلطانی | اول |
| مرتضی قوجازاده | دوم |
| رها جابری | چهارم |
| پروا خلیل زاد | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction Parkinson's disease a neurodegenerative disorder, is the second most common after Alzheimer's disease. The condition is characterized by the degeneration of dopaminergic neurons, which leads to various motor complications such as tremors, rigidity, bradykinesia, and abnormal postural reflexes. Currently, available treatments for Parkinson's disease only alleviate the symptoms and do not cure the disease and they can have serious side effects with prolonged use. L-DOPA is the most effective treatment for restoring dopamine levels in the brain of Parkinson's patients. Mucuna pruriens, a plant that contains L-dopa in its seeds, has been studied as a potential supplement to lower catalepsy in Parkinson's patients. Many studies have been conducted to evaluate the effect of Mucuna pruriens supplementation on Parkinson's patients. In this review, we aim to collect the data related to this research and study the effect of Mucuna pruriens in treating Parkinson's disease. Methods An inclusive systematic literature search was carried out in the electronic databases including PubMed, Scopus, Web of Science, ProQuest, and Google Scholar, Embase up to February 2023 to conduct this systematic review. Two independent researchers evaluated the saved publications, and then selected studies were critically appraised by the ARRIVE checklist for preclinical animal studies by two authors independently. All in-vivo studies related to the impact of Mucuna pruriens were included. Reviews, non-English, and in-vitro studies were excluded. Data such as active compound dose and type of administration, number, and performance of dopaminergic neurons, etc. were extracted. The extraction table was framed with extracted data. Results: 586 relevant publications were retrieved from electronic databases. After thoroughly screening the titles and abstracts and removing duplicates (n=248) 107 studies remained. Full texts of these articles were reviewed, and 31 studies were included. Animal preclinical studies were included that used Parkinson-induced mice or rats as experimental subjects. Most of the included studies were related to the last 15 years. A wide range of Parkinson-related values such as tremors, dyskinesia, Ca2+ concentration, etc. were considered in the articles. Study results showed a significant neuroprotective effect of Mucuna pruriens in parkinsonism model animals. Even some articles investigated the effect of active compounds of this species in contrast to usual forms of L-DOPA (mainly used Parkinson's medication). The impact of velvet beans on behavioral syndromes of Parkinson's in animal subjects was considerable. ARRIVE appraisal checklist reported a low risk of bias for included studies. Conclusion: Due to the lack of medication to cure Parkinson's disease completely, investigating new medications is of significant value. Herbal medications can be a proper replacement for usual Parkinsonism pharmacotherapy. Related to the high dose of L-DOPA in Mucuna pruriens derived compounds of this plant can help with Parkinson's symptoms. |
| کلمات کلیدی |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 12.pdf | 1403/09/17 | 326086 | دانلود |
| 22.pdf | 1403/09/17 | 485302 | دانلود |
