چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | خلیل حاجی اصغرزاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز سلولهای بنیادی |
| کد مقاله | 85539 |
| عنوان فارسی مقاله | اثرات نیکوتین بر دیس لیپیدمی در مدل موش صحرایی مبتلا به کلستازیس و فیبروز کبدی |
| عنوان لاتین مقاله | Effects of nicotine on dyslipidemia in a rat model of cholestasis and hepatic fibrosis |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | بیست و سومین کنگره ملی و یازدهمین کنگره بینالمللی زیست شناسی ایران |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | Tehran |
| سال انتشار/ ارائه شمسی | 1403 |
| سال انتشار/ارائه میلادی | 2024 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1403/06/19 الی 1403/06/21 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://ibs.org.ir/ibc2024 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. |
| نویسنده | نفر چندم مقاله |
|---|---|
| خلیل حاجی اصغرزاده | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Dyslipidemia means abnormal changes in the level of lipids in the bloodstream. Among the various factors that can lead to this disorder, are liver diseases and smoking. Considering that the liver is the main site of the metabolism of lipids, liver damage is associated with impairment of lipid metabolism. This study aimed to investigate the effects of nicotine administration on dyslipidemia in the animal model of cholestasis. The bile duct ligation (BDL) approach was used to establish a rat model of liver fibrosis. Nicotine was administered in high (10 mg/kg) and low (1 mg/kg) doses intraperitoneally. The amounts of triglyceride (TG), cholesterol (Chol), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were measured using a standard colorimetric kit (Pars Azmoon). The results demonstrated that the administration of nicotine alone in healthy rats leads to a significant increase in the level of TG, Chol, and LDL and a decrease in HDL. Also, liver fibrosis causes a substantial increase in TG, Chol, and LDL levels and decreases HDL compared to healthy controls. Administration of nicotine in BDL rats leads to a further decrease in HDL and an increase in TG level but does not affect Chol and LDL. BDL-induced liver fibrosis leads to dyslipidemia in rats. Continuous exposure to nicotine in both healthy controls and BDL rats leads to more changes in the serum level of blood lipids. Therefore, it is recommended to prevent exposure to nicotine to control dyslipidemia in people with liver diseases. |
| کلمات کلیدی | Liver fibrosis; Bile duct ligation; Dyslipidemia; Nicotine |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 20584.pdf | 1403/07/04 | 781556 | دانلود |
| Abstract.pdf | 1403/07/04 | 282797 | دانلود |
