چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| پریسا کنگری | اول |
| عنوان | متن |
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| خلاصه مقاله | Human organs contain a large number of microorganisms, which play critical roles in human health .The microbiota, as one of the most important microorganisms, describes the living microorganisms found in a defined environment, such as oral and gut microbiota. The composition of microbiota varies from site to site. They play a significant role in preventing numerous diseases and can influence human health by producing essential metabolites, metabolizing nutrients and several toxins that prevent the pathogenic invaders, retard their growth producing beneficial microbial products and metabolizing nutrients and toxins of the invader species. The human gut as one of the most complex community of trillions of commensal microbes. The gut microbiota serve several functions including fermentation of food, protection against pathogens(Gut barrier),stimulating immune response, vitamin production. The composition of the gut microbiota is important for supporting all these functions and staying healthy. The gut microbiota includes archaea, bacteria, protists, fungi, and viruses. Generally, the gut microbiota is composed of phyla including Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, Fusobacteria, and Verrucomicrobia, among which Firmicutes and Bacteroidetes are the major types. Cancer remains one of the leading causes of morbidity and mortality worldwide. Given its widespread prevalence, the identification of new anticancer drugs is crucial. There are several different strategies that are effective at preventing cancer. The gut microbiota and their metabolites may induce immunological and cellular pathways to eliminate invading pathogens and trigger an immune response to prevent cancer. The interaction of the healthy gut microbiota with stromal cells and epithelial cells, plays innumerable key regulatory functions. Bacteria also produce potent metabolites single chain fatty acids (SCFAs) i.e., butyrate and propionate that help in the eradication causing cancer genesis via the activation of innate (myeloid cells) and adaptive (CD4+ and CD8+ cells) immune response and even activation of program cell death. Therefore, gut microbiota play a critical role in immunoregulation and in maintaining intestinal health. |
| کلمات کلیدی | prevention , microbiota, cancer |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| abstract.pdf | 1403/07/04 | 141607 | دانلود |
| photo_2024-09-25_11-32-41.jpg | 1403/07/04 | 98119 | دانلود |
