چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سارا سجادی | اول |
| ال ناز تمیزی | سوم |
| فرناز منجم زاده | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Kojic acid is commonly used to treat melasma. Ascorbic acid is often utilized as an antioxidant. These ingredients are commonly used together in extemporaneous preparation [1]. A recent study aimed to evaluate the physicochemical compatibility of kojic acid with ascorbic acid. The mixture of kojic acid and ascorbic acid was combined at a 1:1 ratio using a vortex mixer. Next, 20% w/v water was added and thoroughly mixed. The resulting samples were then placed in an oven for two months. To assess compatibility, DSC and FT-IR methods were utilized. Furthermore, a validated HPLC-UV analytical procedure was used to measure the remaining amount of kojic acid [2]. The ethical code was TBZMED.REC.1394.496. The visual appearance of the mixture underwent a color change. The maintenance of the endothermic peak of azelaic acid at 147°C in the mixture illustrated the initial compatibility of the formulations. The absence of an endothermic peak (202°C) of ascorbic acid in the DSC thermogram of the mixture demonstrated that ascorbic acid was dissolved in the melted kojic acid. The FT-IR data also proved that kojic acid remained intact. The HPLC outcome, indicated 95% of kojic acid remaining in the samples after stress test. The results of DSC, FT-IR, and HPLC proved compatibility between kojic acid and ascorbic acid. In conclusion, using ascorbic acid as an effective antioxidant can be recommended. |
| کلمات کلیدی | Antioxidants Ascorbic Acid Kojic acid |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IMG-20250118-WA0001.jpg | 1403/10/29 | 57631 | دانلود |
| 294.pdf | 1403/05/17 | 341010 | دانلود |
