چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سارا سجادی | اول |
| ال ناز تمیزی | سوم |
| فرناز منجم زاده | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Kojic acid is a natural compound that is used in skincare products to reduce hyperpigmentation. Assessment of the incompatibilities between the drug and excipients is a crucial matter that contributes to enhancing quality. This study examined the compatibility between kojic acid and methylparaben, a pharmaceutical preservative, using thermal and non-thermal methods [1]. A combination of kojic acid and methylparaben was prepared in equal proportions (1:1) using a vortex mixer. Then, a 20% w/v water was added and thoroughly mixed. The resulting samples were placed in an oven at 40°C for two months. Compatibility analysis was conducted using DSC and FT-IR techniques. Additionally, a validated HPLC-UV was used to measure the remaining amount of kojic acid [2]. The ethical number was TBZMED.REC.1394.496. The visual appearance of the mixtures containing kojic acid and methylparaben indicated a change in color. The fact that the DSC thermogram of azelaic acid did not show an endothermic peak at 159°C in the mixture indicated that the formulations were initially incompatible. Furthermore, the lack of stretching vibration peak at 1140 cm-1 in FT-IR data refers to the degradation of azelaic acid. Additionally, the results of HPLC showed that approximately 42% of kojic acid remained in the samples after stress test. The incompatibility between kojic acid and methylparaben was confirmed by the findings of DSC, FT-IR, and HPLC analyses. It is advisable to refrain from using methylparaben as a preservative in a combination of kojic acid. |
| کلمات کلیدی | Kojic acid Methylparaben Preservatives |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| IMG-20250118-WA0002.jpg | 1403/10/29 | 58999 | دانلود |
| 372.pdf | 1403/05/17 | 21748 | دانلود |
