چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سارا سجادی | اول |
| ال ناز تمیزی | سوم |
| فرناز منجم زاده | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction Kojic acid, a tyrosinase inhibitor, is commonly incorporated into skincare items to diminish hyperpigmentation [ Consideration of the possible incompatibilities between the drug and excipients is a crucial topic that improves the quality. To address this, the recent research investigated the compatibility between kojic acid and propyl paraben, a pharmaceutical preservative, utilizing both thermal and non thermal techniques. M ethod The mixture of kojic acid and propyl paraben was made by combining them in equal amounts (1:1) with a vortex mixer. Then, a solution containing 20% w/v water was added and mixed well. These samples were then put in an oven 40 °C for two months. An analysis was done to check the compatibility of the mixture using DSC and FT IR techniques [ 2]. In addition, a validated HPLC UV analytical method was used to measure the remaining kojic acid after it had been subjected to stress [ 3]. The research was conducted under ethical guidelines, with the ethical number being TBZMED.REC.1394.496. Results and Discussion The mixtures containing both kojic acid and propylparaben displayed a change in color, indicating a visual difference. The DSC pattern of the mixture demonstrated a shift in endothermic peaks at 101°C and 146°C, suggesting that the initial compatibility of the formulations was compromised. However, the FT IR analysis revealed that azelaic acid remained unchanged after undergoing the stress test, highlighting a disc repancy due to the low sensitivity of the FT IR method. Furthermore, the HPLC results showed t hat approximately 59.79 ± 3.65% of kojic acid was still present in the tested samples after experiencing the stress test. The findings from both HPLC and DSC methods consistently aligned with each other. C onclusion 9th Research Congress of Students of Medical Sciences Universities in the South-West of the Country The DSC and HPLC analyses confirmed that kojic acid and propylparaben are not compatible. It is The DSC and HPLC analyses confirmed that kojic acid and propylparaben are not compatible. It is recommended to avoid using propylparaben as a preservative in pharmaceutical dosage forms that contain recommended to avoid using propylparaben as a preservative in pharmaceutical dosage forms that contain kojic acid.kojic acid. |
| کلمات کلیدی | Kojic acid Preservative s Propylp araben |
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