Design and Synthesis of the novel multifunctional delivery system based on BSA-coated magnetic iron oxide nanoparticles as an MRI contrast agent and radiosensitizer of GBM brain tumor.

Mortezazadeh, Tohid

اطلاعات کلی مقاله

نویسنده ثبت کننده مقاله	توحید مرتضی زاده
مرحله جاری مقاله	تایید نهایی
دانشکده/مرکز مربوطه	دانشکده پزشکی
کد مقاله	85209
عنوان فارسی مقاله	Design and Synthesis of the novel multifunctional delivery system based on BSA-coated magnetic iron oxide nanoparticles as an MRI contrast agent and radiosensitizer of GBM brain tumor.
عنوان لاتین مقاله	Design and Synthesis of the novel multifunctional delivery system based on BSA-coated magnetic iron oxide nanoparticles as an MRI contrast agent and radiosensitizer of GBM brain tumor.
نوع ارائه	سخنرانی
عنوان کنگره / همایش	سی و نهمین کنگره رادیولوژی ایران
نوع کنگره / همایش	ملی
کشور محل برگزاری کنگره/ همایش	Iran (Islamic Republic)
شهر محل برگزاری کنگره/ همایش	تهران
سال انتشار/ ارائه شمسی	1403
سال انتشار/ارائه میلادی	2024
تاریخ شمسی شروع و خاتمه کنگره/همایش	1403/02/18 الی 1403/02/21
آدرس لینک مقاله/ همایش در شبکه اینترنت	https://www.isr.org.ir/Congress/2023
آدرس علمی (Affiliation) نویسنده متقاضی	Department Of Medical Physics, School Of Medicine, Tabriz University Of Medical Sciences, Tabriz, Iran.

نویسندگان

نویسنده	نفر چندم مقاله
توحید مرتضی زاده	سوم

اطلاعات تفضیلی

عنوان

متن

کلمات کلیدی

GBM, radiotherapy, radiosensitizer, SPIONPs, MRI

خلاصه مقاله

Introduction (Background & Objectives) : Glioblastoma multiforme is the most common and lethal form of primary malignant brain tumor in adults. The poor delivery of therapeutic agents to the tumor site and the unclear delineation of the tumor margins pose a problem in the treatment of this brain tumor. Nanoparticles and drugs, which can selectively accumulate in tumor tissue through a leaky vasculature and the enhanced permeability and retention effect, have demonstrated potential as both therapeutic and diagnostic agents for brain tumors. Superparamagnetic iron oxide nanoparticles (SPIONPs) have been exploited as useful T2-weighted MRI contrast agents with the aim of locating and imaging tumors. 5-aminolevulinic acid (ALA) as a metabolic product is a precursor of protoporphyrin IX (PpIX) in the heme biosynthesis pathway that improves the radiotherapy effect because the resulting PpIX improves the ROS generation in tumor cells upon X-ray irradiation. Material & Methods : In this study, the dual application of Fe3O4-BSA/ALA NPs as potential radiosensitizer and MRI diagnostic probe were investigated. The prepared NPs were fully characterized using FTIR, TEM, DLS, and zeta potential analysis to assess their chemical and physical properties. The cell survival percentage was evaluated through the Alamar Blue metabolic assay and flow cytometry. Results : By evaluating the radiosensitizing ability of these NPs, it was found that the combined treatment with radiotherapy and radiosensitizer improved tumor cell death. For diagnostic purpose, these NPs as MRI contrast agent was assessed, and found that magnetic NPs increased the negative contrast in T2-weighted MRI. Conclusion : Based on these results, it seems that with further studies and testing, Fe3O4-BSA/ALA NPs may find a way from the bench to the bedside and play a role as a theranostic agent in radiotherapy and MRI of brain tumors.

لینک دانلود مقاله

نام فایل	تاریخ درج فایل	اندازه فایل	دانلود
Radiology 2.pdf	1403/05/15	546526	دانلود
lecture 2.jpg	1403/05/15	323527	دانلود
Abstract notes radiology congress.pdf	1403/05/15	3887308	دانلود

Design and Synthesis of the novel multifunctional delivery system based on BSA-coated magnetic iron oxide nanoparticles as an MRI contrast agent and radiosensitizer of GBM brain tumor.