چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | توحید مرتضی زاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 85208 |
| عنوان فارسی مقاله | Methotrexate-targeted MnO2@5-Aminolevulinic Acid Nanoparticles For T1-T2* Dual-modal MR Imaging Of Glioblastoma |
| عنوان لاتین مقاله | Methotrexate-targeted MnO2@5-Aminolevulinic Acid Nanoparticles For T1-T2* Dual-modal MR Imaging Of Glioblastoma |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | سی و نهمین کنگره رادیولوژی ایران |
| نوع کنگره / همایش | ملی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1403 |
| سال انتشار/ارائه میلادی | 2004 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1403/02/18 الی 1403/05/21 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://isr.org.ir/UserProfile/Articles/Article?eventId=2 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department Of Medical Physics, School Of Medicine, Tabriz University Of Medical Sciences, Tabriz, Iran. |
| نویسنده | نفر چندم مقاله |
|---|---|
| توحید مرتضی زاده | اول |
| یاسین ایامی | دوم |
| معصومه دستگیر | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | ntroduction (Background & Objectives) : Molecular magnetic resonance imaging (MMRI) has emerged as a promising imaging modality in glioblastoma multiforme (GBM) diagnosis due to its exceptional sensitivity to minute tissue changes and the ability to penetrate deep into the brain.The novel targeted contrast agent in GBM detection utilized a modified chitosan coating on manganese dioxide (MnO2) nanoparticles. The modification included adding methotrexate and 5-aminolevulinic acid (MnO2/CS@5-ALA-MTX) to target cells with overexpressed folate receptors and breaking down excess hydrogen peroxide (H2O2) in tumor tissue, resulting in increased T1- T2* MRI signal intensity. The nanosystem was fully characterized in in vitro and in vivo. Material & Methods : The novel targeted contrast agent in GBM detection utilized a modified chitosan coating on manganese dioxide (MnO2) nanoparticles. The modification included adding methotrexate and 5-aminolevulinic acid (MnO2/CS@5-ALA-MTX) to target cells with overexpressed folate receptors and breaking down excess hydrogen peroxide (H2O2) in tumor tissue, resulting in increased T1- T2* MRI signal intensity. The nanosystem was fully characterized in in vitro and in vivo. Each study group underwent external field (H) = 3 T, slice thickness = 5 mm, NEX = 3, FOV = 128 ×128 mm2, flip angle = 90°, number of signal averages = 3, matrix sizes = 256×256. T1 relaxation time was obtained with echo time fixed at TE = 11 ms with variable repetition time (TR = 50-2000 ms). Variable echo times (TE = 10, 30, 60, 90, 130, 170, 210, 240, 270, and 350 ms) and a constant TR = 3,000 ms were used to quantify T2 relaxation times. Results : MnO2/CS@5-ALA NPs (72 nm) had no cytotoxicity on cell lines U87MG and NIH3T3 after 24/48 hours. MRI scans of mice with M109 carcinoma indicated significant tumor uptake and NP capacity to improve the positive contrast effect. Conclusion : This developed MnO2/CS@5-ALA-MTX nanoparticle system could exhibit great potential in the accurate diagnosis of U87MG. |
| کلمات کلیدی | Manganese oxide , Glioblastoma multiforme,MRI |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Radiology 2024.pdf | 1403/05/15 | 467993 | دانلود |
| lecture 1.jpg | 1403/05/15 | 326702 | دانلود |
| Abstract notes radiology congress.pdf | 1403/05/15 | 3887308 | دانلود |
