| خلاصه مقاله | Background and aim: This study aimed to investigate the association between dietary acid load
(DAL) and primary osteoporosis.
materials and methods: The methodology employed for this investigation was a cross-sectional
study. From 850 postmenopausal women aged between 50-65 years, a subset of 232 individuals was
selected, comprising 124 women with normal bone mineral density (BMD) and 108 women diagnosed
with primary osteoporosis, following assessment of the eligibility criteria. Demographic
features, anthropometric indices, and levels of physical activity were obtained via the completion of
questionnaires. The identification of osteoporosis was conducted utilizing the dual-energy X-ray
absorptiometry technique. DAL was evaluated utilizing a semiquantitative food frequency
questionnaire that has been confirmed to be both valid and reliable over the past year. Statistical
analyses were carried out using Independent t-test, Mann-Whitney, Chi-square, and adjusted
binary logistic regression methods through the utilization of SPSS/24 software.
Results: There were significant differences between the two groups in terms of age, body mass index
(BMI), number of deliveries, and years after menopause (p < .05). The mean (standard deviation
(SD)) potential renal acid load (PRAL) and net endogenous acid production (NEAP) were higher in
postmenopausal women with osteoporosis than those with normal BMD (PRAL: -13.1 ± 11.1 mEq/day
vs. -10.8 ± 12.7 mEq/day; NEAP: 29.5 ± 8.5 mEq/day vs. 31.2 ± 9.2 mEq/day). The mean
consumption of potassium, magnesium, and calcium in the osteoporosis group was significantly
lower than in the other group (p < .05). There were significant associations between osteoporosis
with PRAL (odds ratio (OR) = 1.030; 95% confidence interval (CI): 1.001 to 1.060, p = .027) and NEAP
scores (OR = 1.041; 95% CI: 1.003 to 1.081, p = .037). The odds of osteoporosis increased by 3%
following one unit increase in PRAL score. Similarly, it increased by 4% with increasing NEAP score
up to one unit.
Conclusion: Dietary patterns that result in elevated Dietary Acid Load (DAL) may
negatively impact bone health. |