چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فاطمه فرضی | اول |
| سید ابوالقاسم محمدی | دوم |
| ابراهیم سخی نیا | سوم |
| عفت علیزاده | پنجم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background/Aim Vesicles secreted to the outside of the cell environment, exosomes, direct communication between cells via their biomolecular contents. Muscle cells with mutations in the dystrophin gene emerges as the phenotype of Duchenne muscular dystrophy (DMD). In the present study, we will examine exosomes by focusing on their effects towards pathogenesis and treatment of muscular dystrophy. Material/Methods All original articles regarding DMD, exosomes, and treatments were collected and main findings were summarized in this work. Results/Conclusion Although the miRNA cargos were reported to be implicated in the pathological effects of DMD, exosome surface peptides may not affect the progression of disease. The profiling studies showed N-exopeptides of PI3K-Akt pathway and exomiRs associated with P53 and TGF-β pathways(Gartz, Lin, Sussman, Lawlor, & Strande, 2020). According to the conducted studies, exosomes secreted from human mesenchymal stem cells have been used as agents that stimulate cell division in order to improving the condition of patients, whose therapeutic effects have been confirmed by measuring creatine kinase and other variable markers of DMD. Exosome mediated inhibition of calcium entry and subsequent inhibition of calpain activation prevented the degeneration of muscle cells, which confirmed through measuring variable factors such as dystroglycan and lactate dehydrogenase(Yedigaryan & Sampaolesi, 2023). However, this protocol needs continuous injections in patients and may promote negative effects in repeated administrations. In other investigations, exosomes reported to be ideal transporter for myostatin and its components CRISPR CAS9 is known because it causes more stability in serum and also reduces toxicity(Majeau et al., 2022). Overall, exosome mediated amendments may help reducing the progression of DMD in patients. |
| کلمات کلیدی | Duchenne muscular dystrophy, Exosome,Treatments |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 22_156_Fatemeh Farzi.jpg | 1403/04/31 | 599576 | دانلود |
| u65d39da03947a6.04059745 (1).docx | 1403/04/31 | 21395 | دانلود |
| G1230compressed.pdf | 1403/05/09 | 189797 | دانلود |
