چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام کمال کاظمی | اول |
| عفت علیزاده | چهارم |
| مهناز صادقی | دوم |
| فرزانه صادقی | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | MicroRNA-150, hepatocellular cancer, cancer progression, prognosis, diagnosis |
| خلاصه مقاله | Introduction: Hepatocellular carcinoma (HCC) is known to be one of the major contributors of cancer-linked death in human (Zhang et al., 2012) .Because many studies have indicated that miRNAs adjust numerous cellular biological processes, they can contribute to the progression of cancer. In this way, miRNAs are able to alter the expression of oncogenes and tumor suppressor genes by targeting the 3′ UTR of certain mRNAs (Shaheen et al., 2018). Recent evidence demonstrated that down-regulation of miRNA-150 promotes progression of HCC through modulating molecular mechanisms (Sun et al., 2016). The aim of this review is to analyze the molecular functions and impacts of the miRNA-150 in HCC using relevant published articles. Material and methods: We gathered and reviewed the results of selected articles published between 2010 and 2023 using “Hepatocellular carcinoma” AND “miR-150” queries. Subsequently the main findings were summarized and discussed. Result: According to the findings of different studies, expression of miRNA-150 in HCC is significantly reduced and act as tumor suppressor. Also, miR-150 targets c-Myb mRNA at 3’UTR and its overexpression leads to a considerable reduction of CD133 positive cancer stem cells and inhibition of sphere formation. Moreover, miR-150 transfer caused cell cycle proteins dysregulation, resulted in arrest and apoptosis in HCC cells. Additionally, miR-150 over expression reversed HCV and malignancy in Egyptian patients. Conclusion: MiRNA-150 overexpression can act as a potential candidate for HCC control and treatment in the future. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 22_145_Elham Kamalkazemi (1).jpg | 1403/04/31 | 611146 | دانلود |
| Program_Book.pdf | 1403/05/02 | 4276550 | دانلود |
| G-1215.pdf | 1403/05/09 | 353984 | دانلود |
| abstract.docx | 1403/04/29 | 20037 | دانلود |
