چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرانک علمی | اول |
| وحیده شهنازی | سوم |
| آرزو عزیزسلطانی | دوم |
| عفت علیزاده | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Keywords: Rejuvenation, mesenchymal stem cells, MiRNA inhibitors, Senescence |
| خلاصه مقاله | Abstract: Background: MicroRNAs are diminutive biomolecules that exhibit regulatory functions, do not code for proteins and oversee gene expression after transcription. Due to their impact on mRNA, they are extensively linked to the development of stem cell cellular senescence, weakening stem cells regenerative capability. Therefore, miRNAs are potential targets for developing anti-aging innovative approaches. This review discusses the studies employed for the inhibition of aberrant aging associated miRNAs in mesenchymal stem cells (MSCs) and their application in reversing aging process. Methods: We have reviewed the results of selected original articles published from 2016 to 2021, which retrieved using following keywords from main medical databases: “microRNAs inhibitors”, “mesenchymal stem cells”, and “ senescence”. Results and Discussion: A number of research projects have examined the function of different antimiR oligonucleotides (miRNA inhibitors) transfection in senescent MSCs. Hong et al., showed that miR‐155‐5p directs MSCs senescence by regulating the Cab39/AMPK signaling pathway, hence, its inhibition could rejuvenate aged MSCs and enhance their cardioprotective effects (Hong et al., 2020). Moreover, Okada et al., rejuvenated senescent MSCs by hsa-miR-195 inhibition through telomerase reactivation which leads to the development of a promising autologous treatment plan for old patients ‘s cardiac repair (Okada et al., 2016). Shi and colleagues demonstrated that miR-199a-5p inhibition facilitated autophagy and ameliorated MSCs senescence by activating the Sirt1/AMPK signaling pathway. Furthermore, the transplantation of anti-microRNA-199a-5p augmented the potential to overcome the progression of pulmonary fibrosis (Shi et al., 2021). The rejuvenation of aged MSCs, by senescence associated miRNAs inhibition would be an ideal approach for providing enough quantity and acceptable quality of them for future therapeutic approaches. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| G-1268.pdf | 1403/05/09 | 380996 | دانلود |
| IMG_20240813_075312_580.jpg | 1403/05/23 | 96453 | دانلود |
