| خلاصه مقاله | Definition ,Epidemiology and burden of Status Epilepticus
Saeid Charsouei,MD,Associate Prof.of Neurology, Fellowship in Epilepsy
Tabriz University of Medical Sciences
The proposed new definition of SE is as follows : Status epilepticus is a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms, which lead to abnormally, prolonged seizures (after time point t1). It is a condition, which can have long-term consequences (after time point t2), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures. This definition is conceptual, with two operational dimensions: the first is the length of the seizure and the time point (t1) .The second time point (t2) is the time of ongoing seizure activity after which there is a risk of long-term consequences. For classification of SE we propose the following four axes:1) Semiology ,2) Etiology,3) EEG correlates ,4) Age.The highest incidence was just over 80 per 100,000 in a prospective Finnish study. Febrile status epilepticus is the most common etiological category in young children, while cerebrovascular disease is the most common in adults. The incidence was higher in men (2 times) than in women and was almost double among blacks compared to whites. Mortality rates ranging from 10 to 50% were reported.Shorvon found overall SE mortality rates ranging from 3 to 11% in children, and 14 to 59% in adults. |