چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | بنفشه یلمه ها |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 84722 |
| عنوان فارسی مقاله | اگزوزوم های سلول های بنیادی در بازسازی قلب. یک رویکرد درمانی معتبر |
| عنوان لاتین مقاله | Stem cell exosomes in cardiac regeneration; a valid therapeutic approach |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | پانزدهمین کنگره بین المللی آزمایشگاه و بالین |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2024 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/11/05 الی 1402/11/08 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://isacl.congressapp.ir/post_view.php?id=42 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| بنفشه یلمه ها | اول |
| فاطمه خاکی خطیبی | دوم |
| رضا رهبرقاضی | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Over the past two decades, stem cell- based therapies have been extensively applied for a variety of challenging diseases and pathological conditions, especially cardiovascular diseases (CVDs). Stem cells are capable of replacing damaged cells and organ regeneration. Emerging studies have proven the therapeutic value of stem cell exosomes (Exos) for cardiac tissue repair and regeneration. It is believed that mesenchymal stem cell (MSC) Exos are potential alternatives to whole- cell therapy because they mimic the biological activity of MSCs. Exosomal cargos could diminish cardiomyocyte apoptosis, and induce cardiomyocyte proliferation, leading to the restoration of injured myocardium after several pathologies. Besides, these Exos recover cardiac function by modulation of inflammatory biomarkers such as CD68. Data have indicated that miR-146a-modified adipose- derived stem cells (ADSCs) Exos can inhibit the release of proinflammatory cytokines and thus reduce further myocardial damage. Exos from other stem cell sources such as cardiac progenitor cells (CPC) exert regenerative potential by providing signal molecules into the cardiac microenvironment. Therefore, CPCs-Exos can contribute to cardiac tissue homeostasis under pathological conditions. Therefore, stem cell Exos seems to be the potential magic bullet to promote cardiac repair and regeneration following various CVDs. Furthermore, the development of novel theranostic methods in terms of Exos provides a great tool for in-time diagnosis and therapeutic interventions in CVD patients. However, the use of Exos for cardiac repair is still in its infancy, and further clinical studies in this context are mandatory |
| کلمات کلیدی | Stem cells; Exosomes; Heart; Regeneration; Treatment |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| congres.pdf | 1403/05/02 | 269060 | دانلود |
| 1.docx | 1403/05/02 | 37845 | دانلود |
| abstract.png | 1403/02/29 | 129491 | دانلود |
| c23.jpg | 1403/02/29 | 355079 | دانلود |
| 2.jpg | 1403/02/29 | 325903 | دانلود |
