چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | بنفشه یلمه ها |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 84721 |
| عنوان فارسی مقاله | اگزوزوم های ادراری؛ بینش نوآورانه در تشخیص و درمان بیماری های کلیوی |
| عنوان لاتین مقاله | Urinary Exosomes; Innovative insight into diagnosis and treatment of renal diseases |
| نوع ارائه | پوسترو سخنرانی |
| عنوان کنگره / همایش | سومین کنگره بین المللی تشخیص های آزمایشگاهی The 3rd International Congress of Laboratory Diagnosis (LD 2024) |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | آنلاین |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2024 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/11/26 الی 1402/11/29 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.ldcongress.com/?lang=fa https://www.ldcongress.com/2024/book?lang=fa |
| آدرس علمی (Affiliation) نویسنده متقاضی | Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| بنفشه یلمه ها | اول |
| رضا رهبرقاضی | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Exosomes, endosomal-based nano-sized vesicles, are involved in cell-to-cell intercommunication. Exosomes are produced under physiological and pathological conditions with prominent distribution in biofluids. In the urinary system, urinary exosomes (UEs), with an average diameter of 20-100 nm, are excreted by renal tubules epithelial cells, glomerular podocytes, and epithelial cells of the genitourinary tract (bladder and prostate). These exosomes harbor several signaling biomarkers, including membrane proteins, transcription factors, and microRNAs. UEs serve as immune effectors for the protection of the urinary tract against bacterial infection via carrying multiple innate immune proteins. Methods: In this study, several sources were searched in numerous databases including PubMed/Medline, Scopus, and Google Scholar using keywords including; exosomes, urinary exosomes, biomarker, renal diseases, etc. Results: Recent findings have confirmed the potential diagnostic properties of UEs in different abnormalities, such as renal tissue injuries. It is thought that rapid and accurate urine assay in terms of UE biomarkers may facilitate noninvasive diagnosis and develop prosperous management programs for patients suffering from kidney disorders. Besides, changes in the UE molecular signature can help us in the comprehension of the various renal diseases. The molecular composition of UEs displays their cellular origin, making them a promising source of biomarkers for kidney dysfunction and structural damage. Conclusion: Despite recent progress in the detection of patient-specific UE proteome and transcriptome, UE research is still in its infancy, and multiomics analysis is becoming an increasingly important area of study. The combination of exosomes and multi-omics analysis may provide an in-depth understanding of cellular changes and the essence of disease |
| کلمات کلیدی | Urine; Exosomes; Biomarkers; Kidney Disease; Diagnostic |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| abstract.png | 1403/02/29 | 97926 | دانلود |
| 1.jpg | 1403/02/29 | 326055 | دانلود |
| 2.jpg | 1403/02/29 | 561697 | دانلود |
| 1.pdf | 1403/05/02 | 611130 | دانلود |
| Screenshot .png | 1403/05/02 | 242749 | دانلود |
| 1.docx | 1403/05/02 | 39063 | دانلود |
