چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | حامد حاجی پور |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 84707 |
| عنوان فارسی مقاله | Engineered Exosome as A Biological Carrier for Encapsulation of Rosmarinic Acid to Enhance Implantation Rate in Mice with Induced Endometritis |
| عنوان لاتین مقاله | Engineered Exosome as A Biological Carrier for Encapsulation of Rosmarinic Acid to Enhance Implantation Rate in Mice with Induced Endometritis |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | 24th Royan International Twin Congress; 2023 |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | Tehran |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/06/07 الی 1402/06/09 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://royancongress.com/AbstractBook%202023%20(Print).pdf |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| حامد حاجی پور | چهارم |
| امیر فتاحی | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Exosome, Implantation, Endometritis, Rosmarinic Acid |
| خلاصه مقاله | Background: Endometritis is a histopathologic condition that affects the proper decidualization and implantation processes of the embryo. In this study, exosome-containing Rosmarinic acid (RA) was used to dampen lipopolysaccharide (LPS)-induced endometritis and subsequently enhance implantation. Materials and Methods: In this study, exosomes extracted from the serum samples were loaded with RA acid and then administrated into the animal groups, including RA, exosome, RA plus exosome (RA+Exo), and RA-loaded exosomes (RALExo) groups. The concentrations of RA or exosomes used in this study was 10 mg/kg, and the compounds were injected into the uterine horn 24 hours following the induction of endometritis. Upon the presence of inflammation detected by the histopathological method, themost proper groups were mated with male mice. The effect of the treatment group on the implantation rate, progesterone levels, and gene expression was assessed by Chicago Blue staining, ELISA, and RT-PCR, respectively. Results: According to the obtained results, RALExo10 and RA10+Exo10 groups exhibited improved pathological alterations, enhanced progesterone levels, increased implantation rate, as well as heightened expression levels of LIF and Muc-16 genes. Besides, the expression levels of inflammatory cytokines, including TGF-β and IL-10, IL-15, and IL-18, were regulated. Conclusion: Our findings indicated that the expression of LIF, Muc-16 genes as well as IL-18, were significantly correlated with serum progesterone concentrations and the implantation rate in the treatment groups. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| royan congress 2023.pdf | 1403/02/26 | 340226 | دانلود |
| certificate.PNG | 1403/02/26 | 567205 | دانلود |
