چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| عزیزه فرشباف خلیلی | اول |
| عذرا بهروزی فرد مقدم | دوم |
| سمیه عبدالعلی پور | سوم |
| امیرمهدی ایرانشاهی | چهارم |
| مهدی امیرپور | پنجم |
| ثریا بابائی | ششم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | IGF-1, IGFBPs, Menopause, Nigella sativa, Osteopenia, Osteoporosis |
| خلاصه مقاله | Background and Aim: Animal studies have shown that Nigella sativa (NS) seed oil can increase Insulin-like growth factor (IGF-1) serum levels. This study aimed to investigate the effect of oral capsule NS on serum levels of IGF-1 and its binding proteins(IGFBP-1,IGFBP-3) in postmenopausal women with bone loss density. Methods: Sixty postmenopausal women of 50 to 65 years with bone loss density randomly received a soft capsule of NS oil 1000 mg or placebo once daily for six months with a 1:1 allocation ratio. DEXA method was used to measure bone density. Serum concentrations of IGF-1, IGFBP-1 and-3, ALT, AST, ALP, Cr, and urea were measured at baseline and after the intervention Results: There were no signicant differences in serum levels of IGF-1, IGFBP-1, urea, Cr, ALT, AST, and ALP between the two groups at the end of six months. How- ever, a signicant increase has been shown in IGFBP-3 between groups after the intervention (Adjusted mean difference: 95% CI: 1.65:0.36 to 2.97; p=0.013). Conclusion: We observed a signicant increase in IGFBP-3 serum levels without any side effects. Additional research with an increased number of participants may be needed for further clarication of its benecial anabolic effects on the GH system. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1402 nutrition.pdf | 1403/02/12 | 109521 | دانلود |
| INC_2024_Abstarct Book_compressed.pdf | 1403/02/12 | 1060470 | دانلود |
| Poster.pdf | 1403/02/12 | 697101 | دانلود |
