چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | علی ریاضی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های گوارش و کبد |
| کد مقاله | 84566 |
| عنوان فارسی مقاله | The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double‑blinded placebo‑controlled trial study |
| عنوان لاتین مقاله | The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double‑blinded placebo‑controlled trial study |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | بیست و سومین کنگره گوارش و کبد ایران |
| نوع کنگره / همایش | ملی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2022 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/09/21 الی 1402/09/24 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://iaghcongress.org/articleitem/518cbe79-b5b6-44dd-9df8-ec7ec7dd559b |
| آدرس علمی (Affiliation) نویسنده متقاضی | the Liver and Gastrointestinal diseases Research Center of Tabriz University of Medical Sciences |
| نویسنده | نفر چندم مقاله |
|---|---|
| مسعود فقیه دینوری | اول |
| فرزانه جعفرزاده | دوم |
| امیررضا جباری پور سرمدیان | سوم |
| ثمانه عباسیان | چهارم |
| زینب نیک نیاز | پنجم |
| علی ریاضی | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Irritable bowel syndrome (IBS) is one of the world’s most common gastrointestinal (GI) disorders, and current treatments do not meet patients’ demands. This study aimed to investigate melatonin’s therapeutic effects on IBS score, GI symptoms, quality of life, and sleep parameters in both groups of IBS patients with and without sleep disorders. Methods In this randomized double-blinded placebo-controlled trial study, 136 patients with a diagnosis of IBS based on ROME IV criteria were enrolled and then divided into two groups respecting having sleep disorders or not. Patients of each group were randomized in a 1:1 ratio to receive melatonin 6 mg daily (3 mg fasting and 3 mg at bedtime) for 2 months (8 weeks). Blocked randomization was used in this process. All patients were evaluated both at the beginning and the end of the trial regarding IBS score, GI symptoms, quality of life, and sleep parameters through valid questionnaires. Results In both groups of patients with and without sleep disorders, a significant improvement was observed in IBS score and GI symptoms, including the severity and the frequency of abdominal pain, the severity of abdominal bloating, satisfaction with bowel habits, disease’s impact on patient’s life, and stool consistency; however, there was no significant improvement in the frequency of defecations per week. In patients with sleep disorders, significant improvement in sleep parameters, including subjective sleep quality, sleep latency, sleep duration, sleep efficiency, and daytime dysfunction, was observed, while in patients without sleep disorders, there was no significant improvement in sleep parameters. In addition, quality-of-life improvement was observed in a significant number of melatonin recipients compared to placebo in both groups of patients. Conclusion Melatonin can be considered an effective treatment for improving IBS score, GI symptoms, and quality of life in IBS patients with and without sleep disorders. It is also effective to improve sleep parameters in IBS patients with sleep disorders |
| کلمات کلیدی | Irritable Bowel Syndrome, Melatonin, Sleep disorders |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 24bfba1c-0b9d-4512-af95-eeceb0102045.pdf | 1403/02/08 | 965086 | دانلود |
| certificate.pdf | 1403/02/08 | 130724 | دانلود |
| melatonin.jpg | 1403/02/10 | 260554 | دانلود |
