چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| پریسا علیرضایی نجف آبادی | اول |
| آناهیتا سلیمانی | چهارم |
| محمد مصطفی پورسیف | پنجم |
| سید حسین خوش رفتار | دوم |
| صبا هادی | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Abstract: Introduction Pancreatic cancer (PC) is a malignancy with few warning signs before the disease reaches its final stages. Currently, the early diagnosis of PC is very difficult because most patients have non-specific symptoms, which leads to delaying the correct diagnosis. In this study, an attempt was made to discover biomarkers based on differentially expressed genes (DEGs) that can act as a driving factor in tumorigenesis. Methods At the beginning of the study, datasets related to Microarray data extracted by using the GEO database. In the following, quality control was checked with PCA. Subsequently, the LIMMA package was utilized to identified DEGs. Furthermore, the TCGA RNA-seq results were employed to validate our findings. Then to identify biological processes and pathways in which genes with differential expression are involved. GeneCards and Reactome databases were used. Lastly, the relationship between the DEGs and survival time of the disease was assessed using the Kaplan-Meier plotter. Results: In the studied data set, a number of genes have significant differential expression (adj.P.val <0.05, Log2FC>3). Among them, three genes FN1, COMP, CXCL5, had increased expression. Then, using the information available in GeneCards and Reactome databases, these genes had regulatory control over vital pathways, including PI3K-Akt-mTOR, cellular immune pathways. And the differential rate has been confirmed by different graphs. Conclusion: This study led to the identification of three genes with increased expression in pancreatic cancer and potentially capable of early detection of this disease. |
| کلمات کلیدی | Pancreatic cancer; biomarker; microarray |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate1501 (2).pdf | 1403/02/05 | 412137 | دانلود |
| Certificate1501.pdf | 1403/02/05 | 307192 | دانلود |
| BookletFinalFileFinalFileFinal.pdf | 1403/03/05 | 13672261 | دانلود |
