| خلاصه مقاله | BACKGROUND: Delivery of optimal nutrition in patients with spinal muscular atrophy
(SMA) is a challenging issue and these children are at risk for both spectra of malnutrition
(undernutrition and overnutrition). Hence, nutritional assessment, delivery of optimal nutrition
and nutritional interventions must be prioritized in patients with SMA. We aimed to describe
the nutritional status and nutrient intake in children with spinal muscular atrophy.
MATERIALS and METHODS: This cross-sectional study was conducted on 12 children
with SMA type 2 and 3 followed at Tabriz Mardani Azari Children's Hospital. We collected
anthropometrics parameters including weight, height, and body mass index (BMI); and 24-
hour dietary intake records in all children. Patients were classified based on Z-scores and
percentiles of height for age, and BMI for age using the Centers for Disease Control (CDC)
growth charts. The percentiles of height for age <15 categorized as stunt and >15 as normal
height. The percentiles of BMI for age <3 categorized as wasting, 3 to 85 as normal, 85 to 95
as overweight and >95 as obese. Dietary energy intakes were compared with energy
requirements for gender and age.
Results: Twelve children with 5 (41.7%) SMA type II and 7 (58.3%) SMA type III were
recruited. The median age of patients was 84.3 ± 28.3 months (range 20 months to 125
months), with 7 (58.3%) female. Four patients (33.3%) were stunting and 8 patients (66.7%)
were normal height and there are no differences between SMA II and SMA III patients.
Based on BMI percentiles, 2 children (16.7%) were wasting, 3 (25%) were normal BMI, 1
(8.3%) were overweight, and 6 (50%) were obese with no differences between SMA II and
SMA III. The patients consumed 1192.5 ± 444.6 kcal. The energy consumption in children
with SMA type 2 (904 ± 193.1 kcal) was significantly lower than SMA type 3 (1398.5 ±
467.6 kcal) (p = 0.035).
Conclusion: The SMA patient are susceptible for both sides of malnutrition (stunting,
wasting and overweight, obesity). Hence, monitoring the nutritional status of SMA children
need to consider routinely and also put emphasis on nutritional interventions to prevent
malnutrition complications. |