چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فاطمه محمدحسینی | اول |
| رضا قاسمی | دوم |
| هادی ولیزاده | سوم |
| پروین ذاکری میلانی | چهارم |
| رضا قربانی | پنجم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Valsartan, Cardiovascular Disease, SPIP, Intestinal Permeability, Blood Pressure |
| خلاصه مقاله | Introduction: Cardiovascular diseases are one of the leading causes of death in different parts of the world. Hypertension, sometimes called arterial hypertension, is a chronic condition in which the blood pressure in the arteries rises. Angiotensin Ⅱ receptor blockers are mainly used for treatment of CVD. Valsartan is a class Ⅲ ARB drug for reducing BP. In this study, single-pass intestinal perfusion (SPIP) technique was used for investigating the intestinal permeability of Valsartan. The aim of this study was to increase intestinal permeability of valsartan loaded in Nano-emulsions and solid Lipid Nanoparticles. Method & material:SPIP was performed in isolated jejunal segments at three Formulation of Valsartan (PEGylated SLN, Non- PEGylated SLN, and Nanoemulsion) to compare intestinal permeability changes against of simple solution of Valsartan. Phenol red was used as a non-absorbable marker. Stability studies were conducted to ensure that the loss of Valsartan could be attributed to intestinal absorption. Outlet samples were analyzed using the developed HPLC method and effective permeability values were calculated by respected formula. Result:The effective permeability value of Valsartan simple solution in the jejunum was 4.129×10^(-3). Also, the effective permeability values of PEGylated and Non- PEGylated SLNs and Valsartan Nano emulsion were found to be 1.7119×10^(-2) , 1.442×10^(-2), and 1.299×10^(-2) cm/sec. The use of nanoparticle formulations led to a significant increase in intestinal permeability of Valsartan. Conclusion:In conclusion, Valsartan can be absorbed only 23% in the intestine. The high aqueous solubility of Valsartan might be a crucial factor for its poor bioavailability. New techniques have shown that the use of nanoparticles like SLNs and nanoemulsions can dramatically increase intestinal permeability. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Fatemeh Mohammadhosseini.jpg | 1403/01/23 | 1931353 | دانلود |
| resid.jpg | 1403/01/23 | 50162 | دانلود |
| Arcims24AbstractsFinal (1).pdf | 1403/01/23 | 43525241 | دانلود |
| certificate1.jpg | 1403/01/23 | 46540 | دانلود |
| certificate.jpg | 1403/01/23 | 330928 | دانلود |
| 1.docx | 1403/02/01 | 16989 | دانلود |
| ketabche.png | 1403/02/01 | 241640 | دانلود |
