چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| رضا قاسمی | اول |
| فاطمه محمدحسینی | دوم |
| سالار عشایری | سوم |
| پرینا اصغریان | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Breast cancer is one of the most common diseases in women, and identifying novel anti-tumor compounds is an important priority in treating this deadly cancer. Falcaria vulgaris (Apiaceae) grows in different parts of Iran and is used for wound healing, gastric ulcers, and some other diseases. Many of its effects are attributed to the presence of coumarins and flavonoids. Furthermore, previous studies revealed that the compounds found in the Apiaceae family possess cytotoxic activity. Hence, there is a rationale to use these compounds in cancer treatment. The aim of this study was to investigate the anti-tumor effects of F. vulgaris extract on the process of tumor development in the mouse model of breast cancer. Methods: Female BALB/c mice at 6–7 weeks of age were subjected to the subcutaneous injection with 1×10^6 viable 4T1 cells. The extracts of aerial parts of F. vulgaris were prepared using Clevenger and Soxhlet apparatus. Studies were performed in four different groups to evaluate the effects of low doses (10 mg/kg) and high doses (20 mg/kg) of this plant extract. Tissues were collected after 28 days and subsequently tested by qRT-PCR, and analyzed by H&E staining. Result: The results of the study showed that a high dose of F. vulgaris extracts significantly inhibited tumor growth and reduced tumor size and volume in the animal model of breast cancer (p0.01). Some of these effects are caused by altered expression of cancer-related genes through inhibition of cell proliferation and the induction of apoptosis genes. Discussion & Conclusion: This study provides evidence that F. vulgaris extract inhibits the proliferation of breast cancer through an apoptosis-dependent pathway. Thus, possibly suggesting a natural resource for future bio-guided isolation of potential antitumor agents. |
| کلمات کلیدی | Breast cancer, Falcaria vulgaris, BALB/c mice, 4T1 cell line, apoptosis, Real-time PCR |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Poster Reza Ghasemi.jpg | 1403/01/23 | 2063234 | دانلود |
| 1.docx | 1403/02/01 | 16926 | دانلود |
| ghavahi.pdf | 1403/03/06 | 233845 | دانلود |
