| خلاصه مقاله | Background and Aim: Thylakoid supplementation has been proven to be beneficial
for weight management. Research studies have shown that thylakoids can lead to significant reductions in weight, waist circumference, and fat mass promoting the excretion of fat
in individuals with obesity. However, the current data from randomized controlled trials
(RCTs) show varying and inconclusive results. This systematic review and meta-analysis
aims to investigate the effect of thylakoid supplementation on weight changes.
Methods: A comprehensive literature search was prepared before conducting a systematic search in several databases up to May 2023. The data were obtained using STATA
version 13. Effect sizes were reported as weighted mean differences (WMD) and 95%
confidence intervals (CI).
Results: Data were collected from seven eligible trials with 4 treatment arms for animal
studies and 4 treatment arms for human studies in which 151 individuals and 114 rat/
mice were compared in terms of weight changes after thylakoid supplementation. Results
showed that although thylakoid supplementation significantly reduced body weight in
animal studies (WMD: -4.489 gr, 95% CI: -7.664, -1.314; P: 0.006) with non-significant
heterogeneity (I2: 9.2%, P: 0.347), the weight loss was not significant in human studies
(WMD: -1.880 kg, 95% CI: -4.363, 0.603; P: 0.138) while the studies did not have
significant heterogeneity (I2: 0%, P: 0.543).
Conclusion: Thylakoid supplementation is associated with significant weight loss or less
weight gain in animals, but no significant weight change was obtained in human studies. |