| خلاصه مقاله | Abstract
Patients Euthyroid in Levels Hormone Thyroid between Relationship
:Engraftment Platelet and Neutrophil Achieve to Time with HSCT before
Study Sectional-Cross Analytic An
1 Tekantapeh Tahsini Sepideh
1 Gholami Nasrin ,
1 Nejati Babak ,*
,Sciences Medical of University Tabriz ,Center Research Oncology and Hematology 1.
Iran ,Tabriz
HSCT allogeneic of indication common most The :Introduction
,HSCT autologous of case the in and ,syndromes myelodysplastic include
effective for target main The .leukemias and ,lymphomas ,myeloma multiple
important most the is which ,HSCT after engraftment is hematopoiesis
HSC which by process the is Engraftment .survival term-long for criterion
hematopoietic all produce and proliferate to way their find BM the in cells
day first the to equivalent is) NE (engraftment Neutrophil .cells subcellular
106 × 500 above reach counts neutrophil when days consecutive three of
to equivalent considered is) PE (engraftment platelet and) 500> ANC (L /
< reaches count platelet the when days consecutive three of day first the
the in platelets received not has patient the that provided ,L / 109 × 20
onset-late most the of one usually is dysfunction Thyroid .days seven last
thyroid of up-follow term-long therefore ,HSCT allogeneic of complications
.recommended is tests function
performed was study analytical sectional-cross This :Methods and Materials
TFT between relationship the investigate to patients transplanted 37 on
.PE and NE achieve to time the and HSCT allogeneic and autologous before
They .HSCT before days three tests 4T and 3,T ,TSH normal had patients All
was tissue thyroid’ patients the of examination and ,euthyroid clinically were
2.89, :mean with 0.32-5.45 was test TSH the of range normal The .normal
1.4 :mean with) 0.8-2 (1 4:T Free and 2.8, :mean with) 1.4-4.2 (1.98 3:T Free
day first the after and ,daily checked was 1H-CBC ,HSCT After .ELISA on based
3 for L / 106 × 500 >remained count neutrophil the if ,L / 106 × 500> ANC of
was PE and ,NE as considered was 500ANC of day first the ,days consecutive
counts platelet the when days consecutive3 of day first the as considered
.L / 109 × 20 > reach
days 10>NE to time of probability the in observed was 6>OR An :Results
the in also ,patients male and UNR the in 2.89>TSH with patients in
27 الی 29 مهر 1401 / ایران، تبریز
19
the in L/mU 2.89>TSH with patients in days 15>PE to time of probability
of probability the in found was CI and value-p significant Statistically .UNR
to time and) 0.036=value-P8.58,=OR (patients male in days 10>NE to time
.(0.041=value-P14.32,=OR (UNR the in 2.89>TSH with patients in days 15>PE
,regression logistic multiple elimination-backward additional on Based
(0.030 =value-P5.53,= OR (gender and) 0.354=value-P2.14,=OR(type disease
of predictors best the were) 0.102=value-P0.20,=OR (3T and) 0.048=ueval-P10.70,=OR (level TSH while ,NE reaching of predictors best the were
.PE reaching
recommended cautiously be can levothyroxine dose Low :Conclusions
euthyroid in HSCT performing before LNR the in 2.8 ≤to TSH achieve to
discharge earlier cause ,PE and NE to times the reduce will which ,patients
future possible of treatment prophylactic the be will as well as ,patients of
comparing require will trials clinical Future .hypothyroidism induced-HSCT
to treatment levothyroxine supplementary without and with subgroups two
.therapy hormonal replacement this of approval or rejection
Patients Euthyroid ,HSCT ,Hormone Thyroid :Ke |