چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | یوسف خدیوی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 84090 |
| عنوان فارسی مقاله | تعیین ضریب تقسیم آب اکتانول بهینه کوجیک اسید برای فرمولاسیون در محصولات پوستی |
| عنوان لاتین مقاله | Determining the optimum Octanol-water partition coefficient of Kojic acid for the formulation of skin products |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | 24مین کنگره ملی و 10مین کنگره بین المللی سالیانه پژوهشی و فناوری دانشجویان علوم پزشکی کشور |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/07/12 الی 1402/07/14 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://traumamon.com/article_196852.html |
| آدرس علمی (Affiliation) نویسنده متقاضی | Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. |
| نویسنده | نفر چندم مقاله |
|---|---|
| یوسف خدیوی | اول |
| فرناز منجم زاده | پنجم |
| جواد شکری | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction:: Skin surface corneocytes limit the skin absorption of many hydrophilic drugs due to their high density, very low permeability, and high resistance to the penetration of substances into the skin and. Kojic acid (KA) is a natural substance that can inhibit the tyrosinase enzyme in melanin synthesis pathway and investigating its therapeutical effects in hyperpigmentation have become a topic of interest in numerous studies. Finding optimum conditions for skin permeation of KA is an important necessity due to KA’s hydrophilic characteristic and poor skin penetration. This study was conducted to determine the optimum pH with the highest octanol-water partition coefficient (LogP) for formulating KA products. Method & material:: In this experimental study, first a saturated solution of KA was prepared in three buffers of acetate (pH=5.1), phosphate (pH=7), and borate (pH=9), and the calibration graph of KA was plotted using UV-HPLC. To obtain Log P of KA, the buffers were mixed with octanol on the shaking incubator, and after phase separation, the amount of KA in octanol, in buffer before and after mixing with octanol was determined by HPLC-UV. Afterwards, based on the area under the curve of each UV peak and the calibration curve, Log P was determined. Result:: The initial concentration of KA in acetate, phosphate, and borate buffers before mixing with octanol was 40.36, 44.24, 44.79 mg/ml; and the concentration of KA in octanol medium was 6.09, 10.32, 8.37 mg/ml; and the KA Log P was -0.75, -0.51, -0.63, respectively. Conclusion:: The optimum Log P for KA was obtained at pH=7; therefore, it is recommended to provide optimal condition for KA absorption by using ingredients which can effectively keep the pH of the product around 7. |
| کلمات کلیدی | Kojic acid; partition coefficient; logp; hplc; formulation |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Abstracts Accepted(1).pdf | 1403/04/15 | 477938 | دانلود |
| 1.pdf | 1403/05/02 | 322923 | دانلود |
| 2.pdf | 1403/05/02 | 324989 | دانلود |
