چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| عایشه قلی زاده هشجین | اول |
| حامد همیشه کار | دوم |
| فرناز منجم زاده | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Salbutamol is a beta-agonist receptor that is used in asthmatic and chronic obstructive pulmonary disease (COPD) patients. This medicine is available in different dosage forms; syrup, metered dose inhaler (MDI) and dry powder inhaler (DPI). In order to formulate a medicine, drug – excipient compatibility is one of the most crucial matters in order to achieve the best quality parameters which could directly influence the patient's safety. For DPI formulations FDA approved excipients are lactose, glucose and mannitol. Also, recently leucine has been used frequently in DPI formulation. In this study compatibility of salbutamol with the mentioned excipient was investigated. Methods and materials: Visually examination, thermo-analytical techniques such as differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR), chromatographic method (HPLC) were used to evaluate any potential incompatibility. Binary mixtures of salbutamol sulfate and excipients were prepared in different ratios (1:1, 1:10 and 1:67.5 similar to commercial form) and stored 2 months at elevated temperature and humidity (40 °C and adding 20% w/w water). samples were analyzed before and after storage. Results: DSC, FTIR and HPLC results confirmed each other except for glucose. All methods confirmed that there is an incompatibility potential with the excipients. HPLC results show the amount of salbutamol was decreased after storage except for glucose while DSC and FTIR show the sign of incompatibility. Conclusion: Findings reveal that excipients used for DPI formulation could be incompatible with salbutamol. In order to find the degradation compounds and pathways, further studies are needed. |
| کلمات کلیدی | Keywords: salbutamol, DPI, drug-excipient compatibility, HPLC |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1.docx | 1403/02/19 | 16696 | دانلود |
| 1.pdf | 1403/02/22 | 167900 | دانلود |
| 1.png | 1403/02/29 | 260513 | دانلود |
| 2.png | 1403/02/29 | 168951 | دانلود |
| 3.png | 1403/02/29 | 814834 | دانلود |
| Aiesheh Gholizadeh Hashjin.jpg | 1402/12/05 | 287485 | دانلود |
