چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | آلکا حسنی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های عفونی و گرمسیری |
| کد مقاله | 84008 |
| عنوان فارسی مقاله | Dysbiosis and Fecal Microbiota Transplant in neurological disorder |
| عنوان لاتین مقاله | Dysbiosis and Fecal Microbiota Transplant in neurological disorder |
| نوع ارائه | پوسترو سخنرانی |
| عنوان کنگره / همایش | پانزدهمین کنگره بین المللی آزمایشگاه و بالین |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/11/25 الی 1402/11/28 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://isacl.congressapp.ir/submissions.php |
| آدرس علمی (Affiliation) نویسنده متقاضی | Infectious and Tropical Diseases Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| آلکا حسنی | دوم |
| وحدت پورطهماسبی | چهارم |
| آیتک خباز | سوم |
| سمانه حسینی | پنجم |
| محمد یزدچی | ششم |
| الهام مهدی زاده فر | هفتم |
| فرزانه رفیع صداقت | هشتم |
| دریا محمدپورکلخوران | نهم |
| سمیه احمدی | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Abstract Background and Aim: Neurological disorders are characterized by the loss and eventual death of nerve cells in the brain or peripheral nervous system, often associated with aging. Alzheimer's disease and Parkinson's disease are significant neurodegenerative conditions. Recent research has highlighted the potential role of gut bacteria in the development of neurological disorders. Imbalances in the gut microbiota can lead to structural changes and contribute to various neurological disorders. Modulating the gut microbiota holds promise as a therapeutic approach. Fecal microbiota transplantation (FMT) has emerged as an innovative intervention for addressing gut dysbiosis and has been approved for treating recurrent Clostridium difficile infections. Its effectiveness in treating other neurological disorders is also under investigation. This study aimed to explore the relationship between dysbiosis and neurological diseases and evaluate the potential of FMT as a treatment for these disorders. Methods: To collect data for this review article, we used PubMed, Scopus, Google Scholar and Medline databases. The keywords used were Alzheimer's disease + dysbiosis or microbiome, Parkinson's disease + dysbiosis or microbiome, Alzheimer's disease + FMT, Parkinson's disease + FMT. Results: In microbiome research, the term 'dysbiosis' is increases the number of harmful bacteria in the gut which causes induction intestinal, systemic disorders and progress neurological disorder. A treatment called Fecal Microbiota Transplantation (FMT) which aims to re-establish a balanced microbiome. Parkinson’s disease (PD) is a progressive and multifactorial neurodegenerative disorder and the second most common cause of mortality after Alzheimer’s disease (AD). The GM has recently received a lot of focus as a possible contribution to the mechanism underlying PD. FMT has been studied as a potential therapeutic modality for PD patients. studies in experimental mice models suggest that altering the GM by long-term FMT delivery might be a unique therapeutic approach for some people with PD. Alzheimer's disease (AD) is a chronic neurodegenerative condition that causes neuronal death. The most current research showed that disruptions in the microbiota-brain axis might cause neuroinflammation and AD. In the brains of AD animals, FMT may reduce Aβ plaques and improve cognitive impairment. Soo-Hyun Park et al. describes the case of a 90-year-old woman who received FMT and had severe CDI and Alzheimer's dementia, this case study describes cognitive improvement in an AD patient following FMT for recurrent severe CDI. Conclusion: In the past decade, there has been a growing interest in the benefits of Fecal Microbiota Transplantation (FMT) for gastrointestinal diseases. Case studies have shown its effectiveness in treating certain diseases. However, FMT's application in neurological disorders like Parkinson's and Alzheimer's is limited. Patients with these conditions often experience gastrointestinal issues, and some studies have suggested positive outcomes of FMT in treating constipation and reducing non-GI symptoms. Developed countries are utilizing FMT in the form of capsules and medicine to address various diseases. Despite the promising future, there is limited information on how FMT affects neurodegenerative disease mechanisms. Nonetheless, it is believed that targeting the gut microbiota may serve as a supplementary treatment for neurological disorders in the future. |
| کلمات کلیدی | Fecal Microbiota Transplantation (FMT), Parkinson's disease, Alzheimer's disease, microbiome, Neurological disorders |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1.doc | 1402/11/25 | 34816 | دانلود |
| 2.jpg | 1402/11/25 | 368214 | دانلود |
