چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرزانه رفیع صداقت | اول |
| آلکا حسنی | دوم |
| وحدت پورطهماسبی | سوم |
| سمانه حسینی | چهارم |
| یلدا صادق پور | پنجم |
| سمیه احمدی | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background and Aim: The interaction between the gut microbiota(GM) and a certain part of the nervous system called the gut-brain axis that plays an important role in mental health. many studies have related the key role in the balance of GM and the balance of health. Dysbiosis leads to a number of neurological disorders, including MS and could lead to the inflammatory condition. In present study, an attempt was made to investigate the a relationship between dysbiosis and MS and the role of Fecal Microbiota Transplantation(FMT) in disease treatment Methods: To data collection for this review article, we used PubMed, Scopus, Google Scholar and Medline databases. The keywords used were multiple sclerosis + dysbiosis or microbiome, multiple sclerosis + FMT. Results: Dysbiosis defined as the inappropriate regulation of gut microbiota, has recently been linked to the pathophysiology of MS, according to a wealth of evidence. Recent research reported significant alterations in GM species and possible associations with pro-inflammatory pathways may cause or worsen the disease. Given the dysbiosis that has been found in people with MS, FMT has been suggested as a potential strategy to restore a balanced GM. FMT of naïve mice into immunized mice decreased microglia and astrocyte activation, BBB (blood–brain barrier) leakage, demyelination, and axonal loss in EAE (Experimental autoimmune encephalomyelitis). This approach is thought to improve intestinal barrier function when the microbiome has been successfully modified. The intestinal barrier's homeostasis is regulated by the GM, partially through the synthesis of Short-Chain Fatty Acids (SCFA) such butyrate, propionate, and acetate. Additionally, SCFA's have a powerful immunomodulatory effect on MS by balancing the T-cell population Conclusion: Gut microbiota is an important factor in regulating the gut-brain axis and evidence shows that it affects human health and disease. Disturbances in the gut microbiota are associated with various diseases such as MS, for which FMT is used as medicine or tablets and capsules, especially in developed countries. Although there is not enough research for MS, it is believed that in the future, therapies that target GM may be useful as an additional treatment for MS. |
| کلمات کلیدی | Multiple sclerosis; FMT; Dysbiosis; gut microbiota |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ms and fmt abbb.doc | 1402/11/23 | 29184 | دانلود |
| 25_1_farzane rafie sedaghat.pdf | 1402/11/23 | 391274 | دانلود |
