چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| بهنام غمامی | اول |
| طوبی قلی خانی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Her2, Imatinib, pharmacokinetic, ;liposome |
| خلاصه مقاله | Breast cancer is one of the top five causes of death in women globally. Current treatment options for various breast cancer subtypes are based on the molecular categorization of the malignant cells. Although imatinib is expected to inhibit breast cancer, its therapeutic effectiveness is limited by off-target cardiotoxicity. Lipid nanoparticles (liposomes and SLNs) have great potential for the delivery of anti-cancer agents due to their rapid uptake, biodegradability. Aptamers can to improve the therapeutic potential of pharmaceuticals by serving as a targeted delivery vehicle. This research aimed to design and formulate HB5 aptamer modified liposomes loaded with IMT and evaluate in vitro characteristics such as particle size, polydispersity index, zeta potential, encapsulation performance, release performance, stability, and cytotoxicity. and investigating the pharmacokinetic parameters of the prepared formulations in Sprague–Dawley SD rats . |
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| behnam ghamamy.docx | 1402/12/08 | 15368 | دانلود |
