چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیررضا ناصری | دوم |
| سعید صدیق اعتقاد | سوم |
| مهناز طالبی | چهارم |
| نیلوفر پوراکبر | اول |
| احسان نصیری | پنجم |
| علیرضا مجدی | ششم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | |
| خلاصه مقاله | Introduction: Cognitive impairment (CI) is a common but neglected sign of multiple sclerosis (MS). Here, the correlation between circulating markers of inflammation, oxidative stress, and neurotrophic factors with the Cambridge neuropsychological test automated battery (CANTAB) task outcomes was determined in MS patients. Method: The CANTAB (paired-associate learning (PAL), reaction time (RTI), rapid visual information processing (RVP), and spatial working memory(SWM)) tasks was completed by the patients. Accordingly, the serum levels of interferon-γ (INF-γ), C-reactive protein (CRP), ciliary neurotrophic factor (CNTF), glial cell line–derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and malondialdehyde (MDA) were measured based on Enzyme-linked immunosorbent assay (ELISA). Result: The cognitively impaired (CI) patients appropriately differentiated from not cognitively impaired (NCI) ones using the CANTAB tasks. The serum levels of MDA, CRP, INF-γ, and GDNF correlated with the cognitive scores in MS patients (p < 0.05). After adjusting for age, sex, disease duration, and disability levels (covariates in a regression model), the MDA, INF-γ, and GDNF factors levels were statistically different between CI and NCI groups (p < 0.05). Conclusion: The serum level of inflammation markers (IFN-γ) and neurotrophic factors (GDNF) are in correlation with cognitive impairments in MS patients. The mentioned markers might predict the cognitive impairment progress and be used as an index of its detection, in addition to neuropsychological assessments, in MS patients . |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| oral.png | 1404/04/30 | 934708 | دانلود |
| bcnc_certificate (1).pdf | 1402/10/24 | 2969076 | دانلود |
