چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سارا سلاطین | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Alzheimer’ s disease (AD) is a progressive neurological disorder that commonly leads to some memory damage, reasoning, and thinking skills [1]. Rivastigmine hydrogen tartrate (RHT) is an effective treatment modality for AD and belongs to the family of medications known as cholinesterase inhibitors [2,3]. Intranasal administration of pharmaceutical compounds is gaining considerable attention as an alternative route for localized/systemic drug delivery. However, insufficient therapeutic efficacy of drugs via this route seems to be a major challenge for development of de novo intranasal formulations. This shortcoming can be overcome by simultaneous utilization of a nanoparticulate delivery system with a polymeric hydrogel network [4,5]. Therefore, the main aim of this study was to develop erodible in situ hydrogel forming systems of poloxamer 407® (P407), capable of prolonging RHT release from the embedded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). |
| کلمات کلیدی | Intranasal, rivastigmine, hydrogel, thermosensitive |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| bcnc_certificate-1.pdf | 1402/10/20 | 207346 | دانلود |
| bcnc_certificate-3.pdf | 1402/10/20 | 209968 | دانلود |
| Poster Timing-1.pdf | 1402/10/20 | 493760 | دانلود |
| Poster 3.pdf | 1402/10/20 | 1103970 | دانلود |
