چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | فرزاد نجفی پور |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات غدد درون ریز |
| کد مقاله | 83723 |
| عنوان فارسی مقاله | Effects of levothyroxine replacement therapy on insulin resistance in patients with untreated primary hypothyroidism |
| عنوان لاتین مقاله | Effects of levothyroxine replacement therapy on insulin resistance in patients with untreated primary hypothyroidism |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | چهاردهمین کنگره بین المللی بیماری های غدد درون ریز و متابولیسم |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/09/01 الی 1402/10/03 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://14iced2023.ir/enindex.php |
| آدرس علمی (Affiliation) نویسنده متقاضی | endocrine research center, tabriz university of medical sciences |
| نویسنده | نفر چندم مقاله |
|---|---|
| حلیمه امیرآزاد | اول |
| هلدا توتونچی | دوم |
| طاهر منظری | سوم |
| وحیده صدرا | چهارم |
| مصطفی نجفی پور | پنجم |
| مجید مبصری | ششم |
| فرزاد نجفی پور | هفتم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | This study investigated the effects of levothyroxine replacement therapy on insulin resistance, lipid profile, and thyroid function in patients with untreated primary hypothyroidism. 105 patients with hypothyroidism with indication for levothyroxine replacement were enrolled in the present study. Insulin, fasting blood glucose and lipid profile were assessed at the beginning of diagnosis and three months after levothyroxine replacement. Insulin resistance was calculated by hemostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Our data revealed a significant reduction in body mass index (27.18 ± 4.27 versus 26.81 ± 4.18 kg/m2, p = 0.028), cholesterol (199.79 ± 37.61 versus 178.10 ± 32.25 mg/dl, p < 0.001), triglyceride (160.41 ± 71.86 versus 146 ± 61.11 mg/dl, p = 0.012), low density lipoprotein-cholesterol (123.54 ± 30.7 versus 107.08 ± 26.98 mg/dl, p < 0.001), fasting insulin (8.91 ± 3.92 versus 8.05 ± 2.65 mIU/l, p < 0.001), and thyroid stimulating hormone (47.47 ± 3.4 versus 2.22 ± 1.84 µIU/ml, p < 0.001) levels before and after drug intervention. However, no statistical differences were observed in HOMA-IR, QUICKI, and high density lipoprotein-cholesterol. In conclusion, in patients with untreated primary hypothyroidism, levothyroxine replacement therapy based on HOMA-IR and QUICKI did not improve insulin resistance; however, lipid profile was significantly improved following levothyroxine administration. This study was registered in the Iranian Registry of Clinical Trials (IRCT) with ID number: IRCT20130610013612N10 on the date 2019-09-02. |
| کلمات کلیدی | Levothyroxine, insulin resistance, thyroid, glucose |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| The 14TH International Congress of Endocrine Disorders 3.pdf | 1402/10/18 | 259850 | دانلود |
| poster-ppt levothyroxin.pdf | 1402/11/03 | 279446 | دانلود |
