| خلاصه مقاله | Acromegaly is a rare and heterogeneous disorder, often caused by a growth hormone-secreting pituitary adenoma. Despite the availability of three treatment modalities (surgery, medical treatment, and radiotherapy), and the approval of new drugs in recent decades, some patients continue to experience active disease despite undergoing treatment. Hence, there is a demand for innovative therapies in the management of acromegaly, which involves the exploration of new formulations for existing drugs and the development of entirely new drugs currently undergoing research. The purpose of this article is to provide an up-to-date review on the diagnosis, treatment, follow-up and genetic screening of acromegaly. The utilization of modern technology in transsphenoidal microsurgery has resulted in modest improvements in outcomes while expanding the range of treatable conditions and enhancing patient safety during procedures.
Advancements in drug formulations have substantially enhanced the effectiveness of treatment for acromegaly, particularly with the development of extended-release formulations and novel drugs. The ongoing progress in somatostatin receptor ligands (SRLs) is expanding treatment options, offering promising avenues for potential new therapies in future clinical practice. Furthermore, identifying genetic mutations enables the targeted screening for associated health issues and establishes the condition within family members prior to the onset of clinical symptoms. |