چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سپیده سیدی صاحباری |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 83662 |
| عنوان فارسی مقاله | The Association of ApoE Genotype and Cognitive Impairment in Multiple Sclerosis (MS): A Systematic Review and Meta-Analysis |
| عنوان لاتین مقاله | The Association of ApoE Genotype and Cognitive Impairment in Multiple Sclerosis (MS): A Systematic Review and Meta-Analysis |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | Eighth MENACTRIMS Congress |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | United Arab Emirates |
| شهر محل برگزاری کنگره/ همایش | Abu Dhabi |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/09/17 الی 1402/09/18 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.sciencedirect.com/science/article/abs/pii/S2211034823007186 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| سپیده سیدی صاحباری | اول |
| امیررضا ناصری | دوم |
| مهناز طالبی | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | ApoE Genotype، Cognitive Impairment، Multiple Sclerosis، Systematic Review، Meta-Analysis |
| خلاصه مقاله | Background/Objective(s) Multiple Sclerosis (MS) is a neuroinflammatory disease with an autoimmune etiology. Cognitive impairment is one of the most prevalent symptoms of MS which affect nearly 40% to 70% of patients. Apolipoprotein E (ApoE) genotype is known to have a significant association with cognitive disorders. The E4 allele of ApoE has shown a significant relation with the increased risk of Alzheimer's Disease (AD) and has been detected in 40–80% of patients with AD. Material(s) and Method(s) Following the PRISMA statement, a systematic search was conducted though Medline via PubMed, Scopus, and ISI web of science and studies which assessed the association between ApoE and cognitive impairment based on the Brief Visuospatial Memory Test - Revised (BVMT-R), the California Verbal Learning Test- II (CVLT-II), and the Delis-Kaplan Executive Function System (DKFES) tests, in MS patients included in this study. Risk of bias was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools and the meta-analysis was conducted with Comprehensive Meta-Analysis (CMA.2) software. Result(s) Out of 224 identified records, 16 records were screened in the title/abstract stage and finally, 3 studies were included. Considering a low risk of bias in these 3 studies, evaluating the cognitive impairment in MS patients showed that, based on BVMT-R (OR: 1.59, 95% CI: 0.88 - 2.86, p=0.12), CVLT-II (OR: 1.59. 95% CI: 0.84 - 3,p=0.15) and DKEFS (OR: 1.54, 95% CI: 0.66 - 3.59, p=0.32) tests, ApoE4 allele doesn't have a significant role in cognitive impairment of MS patients. Conclusion(s) ApoE4 doesn't have a specific association with cognitive impairment in MS patients. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| File_d7ee9a7174334062889cd88dcb26e1c9-63568118.pdf | 1402/12/07 | 139289 | دانلود |
| SEPIDEH SEYEDISAHEBARI MRS.pdf | 1402/12/07 | 44752 | دانلود |
| SEYEDISAHEBARI SEPIDEH MRS.pdf | 1402/12/07 | 101398 | دانلود |
| IMG_8087.jpg | 1402/12/07 | 168302 | دانلود |
| IMG_8089.jpg | 1402/12/07 | 166636 | دانلود |
| IMG_8088.jpg | 1402/12/07 | 353290 | دانلود |
| P307.pdf | 1402/10/20 | 3597499 | دانلود |
| ApoE4.pdf | 1402/11/09 | 1551980 | دانلود |
