چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد برزگر | دوم |
| بیتا پورشیری | سوم |
| خاطره رضازاده | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | super-refractory status epilepticus, ketogenic diet, infantile spasm, antiepileptic drugs |
| خلاصه مقاله | Introduction: Super-refractory status epilepticus (SRSE) is a life-threatening neurological condition with long-term dysfunction and high mortality (16-23%). SRSE is defined as failure of response of status epilepticus to adequately use antiepileptic drugs. There are no specific guideline for treatment of SRSE and the therapeutic strategies are limited. The ketogenic diet (KD) is an alternative treatment option in patients with SRSE that status epilepticus persist for 24-h or more after administration of anesthesia. Methods: In Zahra Mardani Azari Pediatric hospital, a university level III teaching hospital in Tabriz, Iran, we applied KD for 2 children with SRSE from October 2021 to August 2023. Results: One 2.5 years old girl with history of infantile spasm followed sever pneumonia experienced seizures that are not respond to first and second line antiepileptic drugs and she is placed in a medically induced coma with continuous infusion of midazolam. Seizures were not controlled for 3 days. At third day a KD with 3:1 ratio was started for patient using nasogastric tube as enteral feeding with one third of calorie requirement. After 24 h ketone bodies were appeared in the urine and after 48 h seizers were stopped. Her KD are continued and epileptic seizures were disappeared. Second child was a 5.5 years old girl with no history of disease, was experienced seizures that are resistant to antiepileptic drugs and continuous seizures persist for 30 days. On day 30, they admitted to our hospital and KD with 4:1 ratio was initiated. After 24 hours, seizers were ceased. The child continued KD for 2 months then diet was gradually weaned. Conclusion:We concluded that KD is effective in controlling of pediatrics SRES. Further large sample size randomized clinical trials are suggested to verify the therapeutic effects of KD in pediatric SRES. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1.pdf | 1402/11/28 | 8622 | دانلود |
| 23_205_Khatereh Rezazadeh .jpg | 1402/10/06 | 465480 | دانلود |
