چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | میکائیل ملازاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 83575 |
| عنوان فارسی مقاله | ارزیابی طرحهای درمانی رادیوتراپی پرتودرمانی سه بعدی منسجم، پرتودرمانی تعدیلشده شدت و توموتراپی در سرطان پروستات با استفاده از شاخصهای دزیمتری و رادیوبیولوژیکی |
| عنوان لاتین مقاله | Assessment of The Radiotherapy Treatment Plans of Three Dimensional Conformal Radiation Therapy, Intensity Modulated Radiation Therapy and Tomotherapy in Prostate Cancer Using Dosimetric and Radiobiological Indices |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | سومین کنگره بین المللی انجمن علمی دانشجویان رادیولوژی کشور |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | سبزوار |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/07/11 الی 1402/07/12 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://civilica.com/l/132529/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Mikaeil Molazadeh Department of Medical Physics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| میکائیل ملازاده | چهارم |
| اصغر مصباحی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | TCP ، NTCP ، 3D-CRT ، IMRT ، Tomotherapy ، Prostate cancer |
| خلاصه مقاله | Objective: New radiation therapy techniques have been developed in recent years for prostate cancer. The quality of treatment is influenced by the type of treatment technique in terms of dose distribution techniques and also its radiobiological indicators, including the Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP). This research was done with the aim of finding an adequate technique for treating prostate cancer by dosimetric and radiobiological comparison of three-dimensional conformal radiation therapy (3D-CRT) techniques and two new techniques of dynamic intensity modulated radiation therapy (Dynamic-IMRT) and tomotherapy.Methods: In this study, ten patients with high-risk prostate cancer treated with radiation therapy in Madani Hospital of Tabriz were selected. Prostate tumoral tissue as a target and rectum, bladder and femoral head as normal tissues at risk were contoured according to the criteria of RTOG protocol. For each patient, three separate treatment plans were created for all three techniques. Prescribed dose of 70 Gy in 35 fractions was used for all three techniques. Monaco and Precision Accuray treatment planning systems were used for treatment planning. The dosimetric indicators of each treatment plan, including the heterogeneity index, irradiation time, and the minimum, maximum, and mean doses for each patient and each technique were extracted from the dose-volume histogram (DVH) curves. Then, by using the Biosuite software, using DVH data and radiobiological factors, the TCP and the NTCP were calculated based on LKB and RS models. Results: In 3D-CRT technique, the mean dose values of bladder, rectum and head of right and left femoral bones were showed a significant difference compared to the other two techniques. The heterogeneity index of the 3D-CRT was higher than the other two techniques. The NTCP in the LKB model of the 3D-CRT technique was about 10% (range 3-11%) in the rectum, respectively, compared to IMRT and tomotherapy techniques. These numbers for the RS model was about 24% in the bladder and up to 17% in the rectum in 3D-CRT. The TCP parameter in all three techniques was 100%. Conclusion: In 3D-CRT compared to other two techniques and in D-IMRT to tomotherapy, the absorbed dose was higher and as a result the probability of damage and complications of healthy organs was higher. This point was also confirmed by radiobiological models. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| A3-Gavahi.pdf | 1402/10/02 | 198251 | دانلود |
| A3-Article.pdf | 1402/10/02 | 386182 | دانلود |
