چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیر ولیزاده دیزجیکان | اول |
| لیلا واحدی | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Genetic, Road Traffic Accident, polymorphism |
| خلاصه مقاله | Road traffic accidents (RTAs) are a leading cause of injury and death worldwide, imposing substantial social and economic burdens. While well-established risk factors such as driver behavior, road conditions, and vehicle characteristics play significant roles in RTAs, recent research suggests that genetic factors may also contribute to accident susceptibility and severity. Understanding the genetic underpinnings of RTAs could provide valuable insights for targeted prevention strategies and personalized interventions. This systematic review aims to explore the existing body of literature on genetic studies related to RTAs, focusing on genetic variants, gene-environment interactions, and genetic biomarkers associated with accident risk and outcomes. A comprehensive literature search was conducted using electronic databases (WOS, PubMed, Scopus) to identify relevant studies published up until now. The search strategy combined keywords related to genetics, road traffic accidents, and related terms. Only studies written in English and involving human subjects were included. The study selection process followed predefined inclusion and exclusion criteria to ensure the inclusion of relevant and high-quality studies. Data extraction and synthesis were performed to summarize key findings and identify common themes across the selected studies. The initial search yielded many articles, from which a final set of studies meeting the inclusion criteria was identified. The included studies covered a range of genetic factors associated with RTAs, including candidate gene studies, genome-wide association studies (GWAS), and gene-environment interaction analyses. Key findings from the studies included associations between specific genetic variants and accident risk and interactions between genetic factors and environmental variables (e.g., alcohol consumption, fatigue) influencing accident susceptibility. Additionally, studies explored the potential of genetic biomarkers as predictors of accident severity and outcomes. The findings of the systematic review highlight the complex interplay between genetics and RTAs, emphasizing the need for further research in this area. The identified genetic variants and gene-environment interactions provide valuable insights into the underlying mechanisms contributing to accident risk. However, the current evidence is limited in terms of sample sizes, replication of findings, and consistency across populations. Future studies should aim for larger sample sizes, diverse populations, and standardized methodologies to strengthen the evidence base and facilitate meta-analyses. Moreover, longitudinal studies investigating gene-environment interactions and their impact on accident outcomes are warranted. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 27.jpg | 1402/09/14 | 303752 | دانلود |
| 28_425_090db5c5e7e282f1b98c246d5b82da66.jpg | 1402/09/14 | 279860 | دانلود |
| bill.JPG | 1402/09/14 | 78668 | دانلود |
| photo_6041700323594190296_y.jpg | 1402/09/14 | 42339 | دانلود |
| artttt.JPG | 1402/09/14 | 90982 | دانلود |
