| خلاصه مقاله | Introduction :
Non-alcoholic fatty liver disease (NAFLD)- the most common chronic liver disrorder- is considered as the hepatic manifestation of metabolic disorders such as obesity. Due to the strong correlation between the severity of obesity and NAFLD, defining more accurate anthropometric indicators of obesity seems to be necessary. Behind the use of body mass index (BMI), nowadays, a number of indicators such as neck circumference (NC) as well as NC-to-height ratio (NHtR) are used as novel indices for the diagnosis of metabolic disease. Hence, we aimed to study the association between NHtR and obesity-related indices in patients with NAFLD.
Methods:
The proposal of this study was approved by IR.TBZMED.REC.1400.1099. This cross-sectional study included 175 participants (68 men and 107 women) aged 18-50 years and newly diagnosed with NAFLD (based on ultrasonography findings). NC was assessed to the nearest 0.1 cm with the head positioned along the Frankfurt plane, at mid-neck height, using a calibrated plastic tape. Waist circumference (WC), weight and height were measured and NHtR and BMI were calculated, respectively. After midnight fasting, biochemical markers including Triglyceride (TG), high-density lipoprotein cholesterol (HDL) and liver aminotransferases were assessed and obesity-related markers including, lipid accumulation products index (LAP), visceral adiposity index (VAI) and hepatic steatosis index (HSI) were calculated.
Discussion & Conclusion:
It could be concluded that NHtR is associated with obesity- indices such as LAP and could be positively correlated with hepatic changes during NAFLD, through HSI. While, more studies are required to confirm these preliminary findings. |