چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | فرهنوش فرنود |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات کلیه |
| کد مقاله | 83343 |
| عنوان فارسی مقاله | هایپر فسفاتمی غیر قابل انتظار و اختلال عملکرد تاخیری ارگان پیوندی ،گزارش یک بیمار و مروری بر متون |
| عنوان لاتین مقاله | Unexpected hyperphosphatemia and delayed graft function A case report and literature review |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | The 9th International Congress of Iranian Society of Organ Transplantation (IRSOT) Iranian Society of Organ Transplantation (IRSOT) |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | |
| شهر محل برگزاری کنگره/ همایش | شیراز |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/08/09 الی 1402/08/12 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://pazhoohan.tbzmed.ac.ir/general/cartable.action# |
| آدرس علمی (Affiliation) نویسنده متقاضی | Kidney Research Center, Tabriz University of Medical Sciences, Tabriz , Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرهنوش فرنود | اول |
| محمد رضا اردلان | چهارم |
| سپیده زنونی واحد | دوم |
| سیده مینا حجازیان | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Keywords. Total parathyroidectomy, Hyperparathyroidism, Kidney transplantation |
| خلاصه مقاله | Background. Parathyroidectomy (PTX) remains a preferable treatment for dialysis patients with refractory secondary hyperparathyroidism. The main goal of this surgical treatment is maintaining an adequate balance between the prevention of persistent/recurrent disease and avoidance of postoperative hyperparathyroidism. Parathyroid insufficiency occurs infrequently after PTX. Owing to the presence of supernumerary and other glands in the thymus, total suppression of PTH is uncommon even after total PTX without immediate autotransplantation (AT). It seems that constant motivation of elevated phosphorus and decreased 1,25 dihydroxy vitamin D level on isolated cell nests in the thyroid glands, thymus, and cervical fat, account for detectable PTH after total PTX in end-stage renal disease (ESRD) patients. However, in patients with a history of total PTX undergoing successful kidney transplantation, constant stimulation of cell nests is no longer expected due to the well-functioning of the allograft. Unexpectedly, this drop in PTH values through the first postoperative week in kidney-transplanted patients could result in considerable hyperphosphatemia. Production of calcium phosphate particles in the renal luminal tube, could initiate interstitial inflammation, activation of toll-like receptor 4, and finally development of renal damage as named acute phosphate nephropathy (APN). Subtotal parathyroidectomy which involves the resection of three and a half parathyroid glands is considered a better treatment choice for ESRD patients awaiting allograft. Case report. In this study, we described a 35 years old male ESRD patient with a history of total parathyroidectomy that 4 months later received a kidney allograft. The function of the graft remained stable for one week. After that, creatinine levels gradually decreased, and spontaneously the mean of calcium received to 5.6 mg/dl and the mean of phosphorus received to 6.7 mg/dl. It was observed that the function of the graft drastically decreased and after the prescribing recombinant PTH, all of these parameters were normalized and the graft function was stabilized. Conclusion. APN should be considered in kidney transplanted patients with a history of total PTX and acute onset of allograft failure without a well-known reason. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Certificate- Oral Speaker- Farnood 1 (2).pdf | 1402/09/12 | 636467 | دانلود |
| Unexpected hyperphosphatemia and delayed graft function (1).docx | 1402/09/12 | 14256 | دانلود |
