چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | نعیمه مصری علمداری |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات غدد درون ریز |
| کد مقاله | 83260 |
| عنوان فارسی مقاله | Assessment of the anti-inflammatory and anti-glycemic properties of Royal Jelly and Tocotrienol-rich fraction in an experimental study: Does irisin mediate these effects? |
| عنوان لاتین مقاله | Assessment of the anti-inflammatory and anti-glycemic properties of Royal Jelly and Tocotrienol-rich fraction in an experimental study: Does irisin mediate these effects? |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | چهاردهمین کنگره بین المللی بیماریهای غدد درون ریز و متابولیسم ایران |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/09/01 الی 1402/09/03 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://14iced2023.ir/enindex.php |
| آدرس علمی (Affiliation) نویسنده متقاضی | Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| نعیمه مصری علمداری | اول |
| فرزاد نجفی پور | سوم |
| ندا روشن روان | چهارم |
| حلیمه امیرآزاد | پنجم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Irisin, a novel adipomyokine, has been proposed to be a therapeutic agent against obesity-related metabolic disease. Royal jelly (RJ) and tocotrienol-rich fraction (TRF) are suggested to promote obesity and its related problems. This investigation intended to evaluate the glycemic and inflammation-promoting effects of RJ and TRF through irisin action in obese rats induced by a high-fat diet (HFD) that underwent a calorie restriction diet (CRD). Material and Methods: Fifty HFD-fed obese rats received the following interventions: RJ, TRF, or RJ+TRF in combination with a CRD for 8 consecutive weeks. After the investigation, body weight, fasting blood sugar (FBS), irisin, insulin, C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 β (IL-1β), leptin, adiponectin, and insulin resistance (IR) were assessed. Results: After 8 weeks of treatment, significant weight reduction was noticed in rats received RJ and RJ+TRF related to the CRD rats (P<0.001), although this reduction was not considerable in TRF-treated rats. RJ and RJ+TRF supplementation markedly elevated irisin concentrations in CRD rats (P<0.05), but TRF did not. Glycemic indices, inflammatory indices including IL-1b and CRP levels, and leptin concentrations were significantly decreased after RJ, TRF, and their combination were added to CRD (P<0.05). According to the mediational analysis results, irisin mediated the promoting effects of RJ on glycemic hemostasis. Conclusion: Based on the results of this investigation, RJ and TRF are novel nutrients that have the potential to improve obesity-related disorders. This research suggests that RJ exerts its beneficial glycemic regulatory effects through irisin. |
| کلمات کلیدی | Glucose hemostasis, Irisin, Inflammation, Obesity, Royal Jelly, Tocotrienol-rich fraction |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| The 14TH International Congress of Endocrine Disorders1 __.pdf | 1402/10/17 | 267113 | دانلود |
| congress 2.docx | 1402/10/17 | 15585 | دانلود |
