چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| ناهیده قره آغاجی | اول |
| صهبا مفضل | سوم |
| علیرضا سلیمانزاده | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Nanoclays are natural or synthetic aluminosilicates with nanopores structures. Nanoclays have been studied in many biomedical applications such as tissue engineering, enzyme immobilization, and food science. Besides, they have been investigated as nanocarriers in drug delivery systems (DDS) [1] due to their intrinsic features such as appropriate biocompatibility, high surface area, ability for controlled targeted drug release, and relatively high drug loading capacity. Traditional chemotherapy has side effects on healthy cells; therefore, combination of chemotherapy drugs with biocompatible nanostructures can reduce their side effects and improve their accumulation in tumor area [2]. Herein, we reviewed the application of natural nanoclays as nanocarriers in DDS for chemotherapy. For this purpose, a literature search was performed using Google Scholar, PubMed, and AltaVista databases. The keywords were including different natural clays such as “Kaolinite”, “Halloysite”, “Montmorillonite”, “Sepiolite”, and “Palygorskite”, anticancer drugs like “5-fluorouracil”, “curcumin”, “doxorubicin”, and “exemestane”, and “drug delivery systems”. Then, 80 extracted articles were reviewed. Based on the obtained results, of these nanoclays, montmorillonite (MMT) has been used more than others for chemotherapy drugs delivery. It was found that MMT enhances the loading capacity and controlled release of the drugs. Moreover, it has detoxification properties that can cure the side effects of chemotherapy drugs such as exemestane [3]. MMT, halloysite, and Palygorskite were mainly used to deliver the anticancer drug curcumin. The results indicate that among natural nanoclays, MMT has more potential for using as a nanocarrier in DDS for chemotherapy. |
| کلمات کلیدی | Natural nanoclays, Drug delivery systems, Chemotherapy, Anticancer drugs |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Natural nanoclays.png | 1402/08/22 | 268556 | دانلود |
| Natural nanoclays certificate.jpg | 1402/08/22 | 112523 | دانلود |
