چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرانک علمی | اول |
| صفر فرج نیا | دوم |
| جمال محمدیان | سوم |
| عفت علیزاده | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | endogenous , exogenous , post-transcriptiona, Cellular senescence, miRNAs, MSC |
| خلاصه مقاله | Cellular senescence is an irreparable cell cycle halt that progresses with increasing age. Cellular senescence arise in response to endogenous and exogenous stresses, including stable DNA damage, telomere attrition, oxidative stress, irradiation and oncogene activation. Mesenchymal stem cells (MSCs) application in medical area often requires in vitro expansion, which directs cells towards replicative senescence. Aging of MSCs (both in vivo and in vitro) can affect not only their proliferation potential, but also their properties, like immunomodulation, stemness, and secretory profile; therefore, it probably compromises their therapeutic capacity. It is therefore of vital importance to disclose the rudimentary mechanisms of MSCs senescence and to study and define common methods to evaluate MSCs aging condition. MicroRNAs (miRNAs) have emerged as tiny regulators in the gene expression program associated with cellular senescence, especially at the post-transcriptional levels. MicroRNAs are involved in stem cell senescence through major signaling pathwaysP16, P53, SAS. Hence, it is needed to investigate and elucidate the role of microRNAs in the aging of stem cells. The aim of this work is to collect, discuss the types, and mechanisms by which miRNAs regulate aging approaches in MSCs. Methods and materials: In this study, a literature search was performed using key words: aging, senescence, MSCs, microRNAs between 2010 to 2022. Furthurmore the influence of miRNA mimics and inhibitors in improving in vivo biological properties of MSCs were analyzed. Results: The evidence documented in previous studies emphasized that functional deterioration and lose of stemness properties in MSCs happen which restricts the success of therapeutic applications. The microRNAs can steer MSCs during aging. Morover, the alterations of a number of microRNAs could affect the processes behind the aging of MSCs. Conclusion: It is concluded that miRNAs could initiate or conduct MSCs in Senesecnce pathways. Thus, the approaches for tunning aging at post transcriptional level by specific microRNAs mimics or inhibitors might modulate and reverse senescence in MSCs |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| certielmi.pdf | 1402/08/10 | 173459 | دانلود |
| Abstract book-final-61-62_2.pdf | 1402/08/17 | 328857 | دانلود |
