چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | زینب قسمتی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 83002 |
| عنوان فارسی مقاله | طراحی ایمونوانفورماتیک واکسن چند اپیتوپی جدید بر علیه سرطان پروستات |
| عنوان لاتین مقاله | An Immunoinformatics Design of New Multi-Epitope Vaccine Candidate Against Prostate Cancer |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | پنجمین همایش بین المللی و سیزدهمین همایش ملی بیوتکنولوژی جمهوری اسلامی ایران |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/07/16 الی 1402/07/18 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.biotechcongress.ir/fa/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Zeinab Ghesmati1,2, Mohsen Rashid3, Effat Alizadeh2 1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran 2Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran 3Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| زینب قسمتی | اول |
| عفت علیزاده | دوم |
| محسن رشید | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Prostate Cancer (PCa) is introduced as the second most prevalent cancer in the men group. In recent decades, PCa has emerged as a prominent life-threatening condition among older men. Radiation and surgical therapies treat this disease when it first appears in a localized form. Androgen deprivation therapy, hormonal therapy, chemotherapy, and other forms of treatment are frequently utilized as therapeutic strategies. However, many investigations have revealed numerous side effects after using these treatments. In the present study, various immunoinformatic approaches are being used to create a multi-epitope peptide vaccine using the overexpressed antigenic proteins of PCa (including PSMA, PSA, STEAP, PSCA, and PAP). The multi-epitope vaccine was produced utilizing various immunological filters and rigorous immunoinformatic analysis. Although the produced epitopes offer several advantages, they have low immunogenicity, a common issue with epitope vaccines. TLR5 agonist (flagellin) may resolve this problem as a suitable adjuvant. Three peptide linkers, AYY, GPGPG, and KK, attached the anticipated CTL, HTL, and LBC epitopes, respectively. Then, we assessed the developed vaccine's physicochemical characteristics, antigenicity, allergenicity, solubility, and secondary and 3D structures. To produce a 3D structure with high quality for the designed vaccine, refinement, and validation were carried out. In addition, molecular docking revealed a significant binding with the lowest energy between the vaccine element and TLR5. Molecular simulation using normal mode analysis (NMA) showed the stability of docking complexes. A vaccine component has been done in silico cloning of the peptide for its future amplification. As a result, our multi-epitope peptide vaccine is likely to elicit cellular and humoral responses, making it a compelling candidate with appropriate physicochemical and immunological features for PCa therapy. |
| کلمات کلیدی | Keywords: Prostate Cancer, Peptide Vaccine, Immunoinformatics, Epitopes, Adjuvant, In silico Cloning |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ghavahi.jpg | 1402/08/08 | 955875 | دانلود |
| Zeinab-ghesmati_poster.jpg | 1402/08/09 | 2196364 | دانلود |
| 1.docx | 1402/08/22 | 18860 | دانلود |
| feshe varizi.PNG | 1402/08/22 | 62836 | دانلود |
| Ghavahi hozor.jpg | 1402/08/22 | 351526 | دانلود |
