چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| معصومه شریفی آزاد | اول |
| میراحمد مظلومی | دوم |
| رعنا جهانبان اسفهلان | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and morality rate are rising and poses an important threat to the public health. It is known that multiple drug resistance (MDR) is one of the major obstacles in CRC treatment. Tumor microenvironment plus genomic instability, tumor derived exosomes (TDE), cancer stem cells (CSCs), circulating tumor cells (CTCs), cell-free DNA (cfDNA), as well as cellular signaling pathways are important issues regarding resistance. Since non-targeted therapy causes toxicity, diverse side effects, and undesired efficacy, targeted therapy with contribution of various carriers has been developed to address the mentioned shortcomings. In this paper the underlying causes of MDR and then various targeting strategies including exosomes, liposomes, hydrogels, cell-based carriers and theragnostic which are utilized to overcome therapeutic resistance will be described. We also discuss implication of emerging approaches involving single cell approaches and computer-aided drug delivery with high potential for meeting CRC medical needs. |
| کلمات کلیدی | Colorectal cancer, Drug delivery, Artificial intelligence, Exosome, Cancer stem cells |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Sharifi.jpg | 1402/08/07 | 2083105 | دانلود |
| sharifi.docx | 1402/08/07 | 532900 | دانلود |
| sharif.jpg | 1402/08/07 | 355263 | دانلود |
