چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | عفت علیزاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 82971 |
| عنوان فارسی مقاله | استفاده از داربست های مبتنی بر سلولز برای تحویل microRNA برای ترمیم نقایص استخوانی |
| عنوان لاتین مقاله | Use of cellulose-based scaffolds for microRNA delivery for bone defect repair |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | تازه های علوم و فناوری های نوین پزشکی |
| نوع کنگره / همایش | ملی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تبریز |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/02/16 الی 1402/02/18 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | congress.tbzmed.ac.ir |
| آدرس علمی (Affiliation) نویسنده متقاضی | 1Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرشته راهدان | اول |
| محمدرضا کندی | سوم |
| دنیا شاطرابادی | پنجم |
| عفت علیزاده | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Bioengineered composite scaffolds comprising of multifunctional biomaterials in mixture with the cells and bioactive therapeutic mediators have great potential for renewal and bone repair. There has been developing attention in the usage of bacterial cellulose (BC), “a 3-D hierarchical system usual biopolymer free of hemicellulose and lignin” as biomaterial designed for the creation of biocomposite scaffold. Among the various biofactors, microRNAs (miRNAs) have important regulatory roles in the growth, differentiation and function of bone cells. This review will highlight the different classifications of cellulose-based composite scaffolds used in bone effective microRNAsdelivery that participate in bone regeneration. Method: Original articles from year 2000 up to now about cellulose-based scaffolds used in specific microRNAs delivery for bone repair and construction have been searched from Google Scholar, Web of Science, and PubMed databases. Using these data, scaffolds characteristics that are based on cellulose and cellulose derivatives and those applied for miRNA delivery were discussed and investigated. Result: Cellulose-based scaffolds have properties such as fibrous aspect, improved surface reactivity, excellent biocompatibility, high crystallinity, biodegradability, notable mechanical properties and non-toxicity. It seems that cellulosic derived scaffolds are novel and competent molecules, which can be employed in the effective transfer of microRNAs that are involved in bone tissue engineering by changing the expression of several genes and valuable pathways involved in bone formation. Conclusion: Cellulose-derived scaffolds appear to be a novel generation of molecules that have cost effectiveness, proficient in tissue engineering. The miRNA transfer with the help of cellulose-based scaffolds could have advantages related to the repair of bone defects. excellent biocompatibility, biodegradable and low immunogenicity properties that can be proficient |
| کلمات کلیدی | Tissue engineering, Bone regeneration, Cellulose-based scaffolds, miRNA |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| FR-EA-1.JPG | 1402/10/05 | 43727 | دانلود |
| FR-EA-2.JPG | 1402/10/05 | 60564 | دانلود |
| FR-EA-3.JPG | 1402/10/05 | 15341 | دانلود |
| FR-EA-cer.pdf | 1402/10/05 | 162674 | دانلود |
