چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | عفت علیزاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 82932 |
| عنوان فارسی مقاله | RNA غیر کد کننده کوچک به عنوان نشانگرهای زیستی جدید در تشخیص سرطان سر و گردن |
| عنوان لاتین مقاله | Tiny non coding RNA as novel Biomarkers in the diagnosis of Head and Neck Cancer |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | تازه های علوم و فناوری های نوین پزشکی |
| نوع کنگره / همایش | ملی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تبریز |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/02/16 الی 1402/02/18 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://congress.tbzmed.ac.ir/amst/fa/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرزانه صادقی | اول |
| مهناز صادقی | دوم |
| عفت علیزاده | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Head and neck/oral cancer; HNOC; MicroRNA; biomarker, dignosis |
| خلاصه مقاله | Introduction: Head and neck/oral cancer(HNOC), a heterogeneous group of tumors that extend from the oral cavity to the upper gastrointestinal tract, is the sixth most common cancer worldwideaccounting for 4% of cancers in men and 2% of cancers in women. Despite the development of advanced treatments, the prognosis forthese patients has remained unchanged for decades. Thus, more effective prognostic and diagnostic biomarkers are urgently required for early detecting of HNOC which facilitates timely treatment. Accumulating evidence suggests that microRNAs, small single-stranded non-coding RNAs, play important roles in many human cancers. MicroRNAs are pivotal regulators of diverse cellular processes including proliferation, differentiation, apoptosis, survival, motility, and morphogenesis.This will lead to the identification of specific microRNA expression patterns that may become powerful biomarkers for diagnosis and prognosis of HNOC. The present review aimed to provide a detailed overview of the most extensively studied MicroRNAs that are aberrantly expressed in HNOC and highlighting their utility as biomarkers. Materials & Methods: A literature review was performed using PubMed, Scopus and Web of science databases.All articles publishedbetween 2012 and 2022 that analyzed the circulating microRNAs with probability to be used as biomarkers in head and neck cancer. Result: MicroRNAs play critical roles in the overall surveillance outcomes by functioning either as promoting tumor miRNAs (onco-miRNAs) or as tumor suppressor miRNAs, whose over or underexpression respectively leads to cancerous growth. In HNOC, families of miR-21, miR-31, miR-99a and miR-142 were generally overexpressed while families of miR-125, miR-145 and miR-199 were mainly underexpressed. However, some controversies can be found with miR-15, miR-30, miR-155, miR-375 families, which have been described to work both as onco-miRNA and tumor suppressor miRNAs. Conclusion: MicroRNA knowledge provides opportunities for early diagnosis and subsequent monitoring of HNOC in a less invasive, simple manner, allowing for serial sampling to evaluate presensence, treatment response, and minimal residual disease. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Tiny non-coding RNAas novel Biomarkers in the diagnosis of Head and Neck Cancer.pdf | 1402/08/06 | 91871 | دانلود |
| FS-EA1.JPG | 1402/10/04 | 52534 | دانلود |
| FS-EA2.JPG | 1402/10/04 | 58339 | دانلود |
| FS-EA3.JPG | 1402/10/04 | 28518 | دانلود |
| FS-EA4.JPG | 1402/10/04 | 36656 | دانلود |
