چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مینا اسلامبولچیلار |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده داروسازی |
| کد مقاله | 82902 |
| عنوان فارسی مقاله | ارزیابی تأثیرات پیشگیرانه عسل منطقه سیهرود )تبریز( و کتوتیفن بر دردهای نوروپاتیک حاصل از وینکریستین در موش سوری |
| عنوان لاتین مقاله | Evaluation of preventive effects of honey from Siehroud region (Tabriz) and ketotifen on neuropathic pain caused by vincristine in mice |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | پنجمین کنگره بین المللی و بیست و ششمین کنگره فیزیولوژی و فارماکولوژی ایران |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | سمنان |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/07/19 الی 1402/07/21 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://koomeshjournal.semums.ac.ir/article-1-8066-fa.html |
| آدرس علمی (Affiliation) نویسنده متقاضی | 1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مسلم نجفی | دوم |
| بهلول حبیبی اصل | سوم |
| مینا اسلامبولچیلار | اول |
| حسین سرخانی | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction: Various mechanisms are involved in vincristine neuropathy (including activation of oxidative stress, inflammation, etc.). Honey's antioxidant-rich composition and ketotifen's anti-inflammatory effects could potentially improve the performance of the nervous system. This study sought to explore the potential of honey and ketotifen to prevent neuropathic pain induced by vincristine in mice. Materials and methods: Eighty-one male mice, weighing between 25 and 35 grams, were randomly divided into nine groups (saline, vincristine, honey 5, 10, 20 mg/kg, IP; ketotifen 2, 4, 8 mg/kg, IP; and honey 5mg/kg plus ketotifen 2mg/kg, IP) and treated for 25 days. Different doses of honey and ketotifen were injected three days before the vincristine. On the fourth day, vincristine (1 mg/kg, IP ) was injected. Then the honey and ketotifen treatment was continued for 3 days. After that, we have 3 days to rest. The next day, we performed a hot plate test. This 7-day cycle was repeated 3 times for all groups. On day 25, blood samples were collected for MDA and TAC estimation. Result: The results indicated a significant protective effect of different doses of honey and ketotifen on vincristine-induced neuropathic pain. Treatment with both honey and ketotifen didn’t have a significant protective effect. Also, treatment with honey (5mg/kg, IP) and ketotifen (8mg/kg, IP) could significantly increase the TAC level. Additionally, treatment with honey (20mg/kg, IP) and ketotifen (2mg/kg, IP) together, could significantly decrease the MDA levels. Interestingly, treatment with both honey and ketotifen significantly changed both biomarkers levels. Conclusion: Honey and ketotifen alone and together were effective in preventing vincristine-induced neuropathic pain, but the mechanism could not be completely attributed to the suppression of oxidative stress. |
| کلمات کلیدی | Vincristine, Neuropathy, Honey, Ketotifen, Oxidative stress |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| koomesh-v25n5p25-fa.pdf | 1403/01/20 | 333371 | دانلود |
| semnan poster.pdf | 1403/01/21 | 2292709 | دانلود |
