چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | عفت علیزاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 82894 |
| عنوان فارسی مقاله | پیشرفت های اخیر در مهندسی شیت سلولی با استفاده از پلیمرهای زیستی مبتنی بر پپتید با هدف پیوند موفقیت آمیز |
| عنوان لاتین مقاله | Recent Advances in Cell Sheet Engineering Using Peptide-Based Biopolymer Towards Successful Transplantation |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | تازه های علوم و فناوری های نوین پزشکی |
| نوع کنگره / همایش | ملی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تبریز |
| سال انتشار/ ارائه شمسی | 1402 |
| سال انتشار/ارائه میلادی | 2023 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1402/02/16 الی 1402/02/18 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://congress.tbzmed.ac.ir |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام نوروز دولت آبادی | اول |
| عفت علیزاده | دوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Cell sheet engineering, Peptide, Thermosensitive/thermoresponsive polymer. |
| خلاصه مقاله | Cell sheet engineering has become a significant subject of study in regenerative medicine and tissue engineering because of the enhanced survivability and simplicity of transplanting cells to target areas. A thermosensitive polymer, more intensively used poly N-isopropyl acrylamide (pNIPPAM), makes it easier to release cell sheet upon sol-to-gel transitions in temperatures below the low critical temperature (LCST) without intrusive effects of a protease like trypsin. This literature review's focus is on peptide-based thermoresponsive polymers-mediated cell sheet technology. Recently, a number of researches focused on peptide-based thermosensitive matrix-mediated cell sheet engineering due to the distinct chemical, physical, and biological features of peptides. A comprehensive search was performed in different databases including PubMed, Embase, and Google Scholar. The query keywords were Cell sheet engineering, Peptide, and Thermosensitive /thermoresponsive polymer. The general design, optimization, LCST, biocompatibility, and release behavior of peptide polymers were evaluated, compared, and discussed. Four designs were found either individually or in combination with other items: Three amino acid peptides (RGD), Four amino acid peptides modified of RGD (RGDS), Poly-L lysin (pεK), and Elastin Like Peptide (ELP). RGD design showed that coating the culture surface with RGD (Arg–Gly–Asp) peptide was able to facilitate cell growth, cell sheet construction, and harvest without enzymatic treatment. The ArgGlyAspSer [RGDS] as a modified form of RGD stimulates cell adhesion, so fixing this peptide at the surface of a stimuli-responsive dish speeds up the process of cell sheet formation. pεK exhibited thin, transparent, porous, and robust properties. And adding the synthetic cell-binding peptide H-Gly-Gly-Arg-Gly-AspGly-OH (RGD) or the 21 integrin recognition sequence H-Asp-GlyGlu-Ala-OH (DGEA) to the pεK hydrogel improved its ability to promote cell adhesion. ELPs are a powerful engineering platform that aggregates sharply above a temperature at which they undergo an inverse phase transition. ELPs were employed single or in hybrid form with RGD or other biomolecules. The results of designed peptide polymers were comparable and better than chemical polymers, hence utilizing peptide-based polymers, their derivatives, and optimizations seems necessary. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| poster.pdf | 1402/08/09 | 939373 | دانلود |
| full paper.pdf | 1402/08/09 | 298126 | دانلود |
| certificate.pdf | 1402/08/09 | 206236 | دانلود |
