چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| حسن امینی | اول |
| رضا رهبرقاضی | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Cardiovascular diseases, especially myocardial infarction, are the leading cause of human mortality and disability in the clinical setting. Surgical modalities and anti-thrombotic therapy are currently the main available approaches in the clinical setting. In recent decades, the application of stem cells and their secretome content such as exosomes has led to the alleviation of incurable pathological conditions. Stem cells and exosomes can expedite the regeneration mechanisms within the injured sites via the alteration of specific signaling pathways. Along with the application of stem cells and exosomes in different tissues, cardiovascular diseases are at the center of attention for therapeutic purposes. Physical and anatomical properties of heart tissue and lack of enough retention time hurdle the application of stem cells and other therapeutics within the heart tissue. Besides, preparation processes and physical stress can lead to the loss of transplanted cells and rapid exosome removal. During the last decades, the application of microneedle patches has contributed to the efficient delivery of exosomes and cells into the target sites. Microneedle patches consist of arrays of needles with an average size of 50-1200 nm for painless delivery of loaded cargoes. Recent data have highlighted the eligibility of microneedle patches for targeted delivery of therapeutics into the cardiac tissue after being placed on the injured sites with proficient regenerative outcomes. |
| کلمات کلیدی | Cardiovascular disease; Stem Cells; Exosomes; Microneedle Patch |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2023-10-14_063206seman.jpg | 1402/07/22 | 213767 | دانلود |
| phypha26-11600962_2_230828124842.pdf | 1402/07/22 | 315718 | دانلود |
| Semnan abstract.docx | 1402/07/22 | 14954 | دانلود |
